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Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cells

2017-02-01Artigo científico Acesso aberto
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dc.contributor.authorFeliciano, Amélia
dc.contributor.authorVaz, Fátima
dc.contributor.authorTorres, Vukosava M.
dc.contributor.authorValentim-Coelho, Cristina
dc.contributor.authorSilva, Rita
dc.contributor.authorProsinecki, Vesna
dc.contributor.authorAlexandre, Bruno M.
dc.contributor.authorCarvalho, Ana S.
dc.contributor.authorMatthiesen, Rune
dc.contributor.authorMatthiesen, Rune
dc.contributor.authorMalhotra, Atul
dc.contributor.authorPinto, Paula
dc.contributor.authorBárbara, Cristina
dc.contributor.authorPenque, Deborah
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier
dc.date.accessioned2023-05-26T22:22:20Z
dc.date.available2023-05-26T22:22:20Z
dc.date.issued2017-02-01
dc.descriptionFunding: Project partially supported by Harvard Medical School-Portugal Program (HMSPICJ/0022/2011), ToxOmics - Centre for Toxicogenomics and Human Health (FCT-UID/BIM/00009/2013), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal) and postdoctoral fellowship (SFRH/BPD/43365/2008) of Fundação para a Ciência e a Tecnologia (FCT), Portugal.
dc.description.abstractWe have examined the effects of Obstructive Sleep Apnea (OSA) on red blood cell (RBC) proteome variation at evening/morning day time to uncover new insights into OSA-induced RBC dysfunction that may lead to OSA manifestations. Dysregulated proteins mainly fall in the group of catalytic enzymes, stress response and redox regulators such as peroxiredoxin 2 (PRDX2). Validation assays confirmed that at morning the monomeric/dimeric forms of PRDX2 were more overoxidized in OSA RBC compared to evening samples. Six month of positive airway pressure (PAP) treatment decreased this overoxidation and generated multimeric overoxidized forms associated with chaperone/transduction signaling activity of PRDX2. Morning levels of overoxidized PRDX2 correlated with polysomnographic (PSG)-arousal index and metabolic parameters whereas the evening level of disulfide-linked dimer (associated with peroxidase activity of PRDX2) correlated with PSG parameters. After treatment, morning overoxidized multimer of PRDX2 negatively correlated with fasting glucose and dopamine levels. Overall, these data point toward severe oxidative stress and altered antioxidant homeostasis in OSA RBC occurring mainly at morning time but with consequences till evening. The beneficial effect of PAP involves modulation of the redox/oligomeric state of PRDX2, whose mechanism and associated chaperone/transduction signaling functions deserves further investigation. RBC PRDX2 is a promising candidate biomarker for OSA severity and treatment monitoring, warranting further investigation and validation.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9
dc.format.extent1052856
dc.identifier.doi10.1016/j.bbadis.2016.11.019
dc.identifier.issn0925-4439
dc.identifier.otherPURE: 61692885
dc.identifier.otherPURE UUID: 351a9468-f994-4aff-8369-f8b7c7c6cb59
dc.identifier.otherScopus: 85006716913
dc.identifier.otherPubMed: 27864139
dc.identifier.urihttp://hdl.handle.net/10362/153237
dc.identifier.urlhttps://www.scopus.com/pages/publications/85006716913
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiomarkers
dc.subjectObstructive sleep apnea
dc.subjectPeroxiredeoxin-2
dc.subjectRed blood cells
dc.subjectMolecular Medicine
dc.subjectMolecular Biology
dc.titleEvening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructive sleep apnea red blood cellsen
dc.title.subtitleCorrelation with polysomnographic and metabolic parametersen
dc.typejournal article
degois.publication.firstPage621
degois.publication.issue2
degois.publication.lastPage629
degois.publication.titleBiochimica et Biophysica Acta - Molecular Basis of Disease
degois.publication.volume1863
dspace.entity.typePublication
person.familyNameMatthiesen
person.givenNameRune
person.identifier1319342
person.identifier.ciencia-idBB1A-A606-EE77
person.identifier.orcid0000-0002-6353-2616
person.identifier.scopus-author-id9741897800
rcaap.rightsopenAccess
relation.isAuthorOfPublication67181d3c-b83e-4151-9a74-0ea14aeb7f05
relation.isAuthorOfPublication.latestForDiscovery67181d3c-b83e-4151-9a74-0ea14aeb7f05

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