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Change in different classes of chronic back pain suspicious of axial spondyloarthritis

2024-09-30Artigo científico Acesso aberto
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dc.contributor.authorBosch, Philipp
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorMarques, Mary-Lucy
dc.contributor.authorvan der Heijde, Désirée
dc.contributor.authorLandewé, Robert
dc.contributor.authorvan Lunteren, Miranda
dc.contributor.authorde Bruin, Liese
dc.contributor.authorde Hooge, Manouk
dc.contributor.authorBastiaenen, Caroline
dc.contributor.authorExarchou, Sofia
dc.contributor.authorRamonda, Roberta
dc.contributor.authorFagerli, Karen Minde
dc.contributor.authorvan Gaalen, Floris A
dc.contributor.authorRamiro, Sofia
dc.contributor.authorRamiro, Sofia
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2024-10-01T22:28:38Z
dc.date.available2024-10-01T22:28:38Z
dc.date.issued2024-09-30
dc.description© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractOBJECTIVES: To follow up four previously identified classes 'pure axial spondyloarthritis' (axSpA) ('axial'), 'axSpA with peripheral signs' ('inflammatory back pain+peripheral'), 'axSpA at risk' and 'no spondyloarthritis' ('no SpA'). They reflect the expert-opinion-free construct or 'Gestalt' of chronic back pain suspicious of axSpA. The aim was to assess participants' transitions between these classes over time. METHODS: Participants with chronic back pain of ≤2 years duration, suspicious of axSpA from the SPondyloArthritis Caught Early cohort were analysed. Latent class (LCA) and latent transition analysis (LTA) using clinical, laboratory and imaging data at baseline and 2 years were calculated. Conditional and marginal probabilities were obtained, reflecting the probability of a spondyloarthritis feature in a class and the probability of the participant's class membership, respectively. Transitional probabilities were extracted revealing potential switches across classes. The analyses were performed in all participants using imputations for missing data and in participants with full data at baseline and 2 years. RESULTS: Baseline and 2 years LCA models were constructed for 702 participants, resulting in the same four-class model as previously described. LTA revealed only a 3% transition from the 'no SpA' to the 'at-risk' class from baseline to 2 years with all other participants remaining in their initially assigned class. Sensitivity analysis on 384 participants with complete data at both baseline and 2 years showed similar results, underlining the model's robustness. CONCLUSIONS: Transitions between the four classes over 2 years were basically inexistent, highlighting the unlikelihood of developing new class-defining features of axSpA after an initial clinical workup.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent906412
dc.identifier.doi10.1136/rmdopen-2024-004584
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 100415417
dc.identifier.otherPURE UUID: 6aaea09b-684e-46f5-a44e-46be22b9447f
dc.identifier.otherPubMed: 39349053
dc.identifier.otherScopus: 85205446509
dc.identifier.otherWOS: 001324926700001
dc.identifier.urihttp://hdl.handle.net/10362/172822
dc.language.isoeng
dc.peerreviewedyes
dc.subjectHumans
dc.subjectMale
dc.subjectFemale
dc.subjectBack Pain/etiology
dc.subjectAdult
dc.subjectChronic Pain/etiology
dc.subjectAxial Spondyloarthritis/diagnosis
dc.subjectMiddle Aged
dc.subjectLatent Class Analysis
dc.subjectCohort Studies
dc.subjectDisease Progression
dc.subjectSpondylarthritis/diagnosis
dc.titleChange in different classes of chronic back pain suspicious of axial spondyloarthritisen
dc.title.subtitlea latent transition analysis of the SPACE cohorten
dc.typejournal article
degois.publication.issue3
degois.publication.titleRMD Open
degois.publication.volume10
dspace.entity.typePublication
person.familyNameSepriano
person.familyNameRamiro
person.givenNameAlexandre
person.givenNameSofia
person.identifier397398
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.ciencia-idC513-D4F1-EEC3
person.identifier.orcid0000-0003-1954-0229
person.identifier.orcid0000-0002-8899-9087
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication9853406a-2641-440d-a8b1-a516bdb6f32f
relation.isAuthorOfPublication.latestForDiscovery9853406a-2641-440d-a8b1-a516bdb6f32f

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