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Nanostructured Metal Oxide Sensors for Antibiotic Monitoring in Mineral and River Water

2022-05-29Artigo científico Acesso aberto
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dc.contributor.authorMagro, Cátia
dc.contributor.authorMoura, Tiago
dc.contributor.authorDionísio, Joana
dc.contributor.authorRibeiro, Paulo A.
dc.contributor.authorRaposo, Maria
dc.contributor.authorSério, Susana
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionLIBPhys-UNL
dc.contributor.pblMDPI AG
dc.date.accessioned2022-08-26T22:17:38Z
dc.date.available2022-08-26T22:17:38Z
dc.date.issued2022-05-29
dc.descriptionFunding Information: This research was supported in part by Fundação para a Ciência e a Tecnologia (FCT), Por-tugal, through the research center Grants No. UIDB/FIS/04559/2020 and No. UIDP/FIS/04559/2020 (LIBPhys), from FCT/MCTES, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractAntibiotics represent a class of pharmaceuticals used to treat bacterial infections. However, the ever-growing use of antibiotics in agriculture and human and veterinary medicine has led to great concern regarding the outbreak of microbe strains resistant to antimicrobial drugs. Azithromycin, clarithromycin, and erythromycin are macrolides, a group of molecules with a broad spectrum of antibiotic properties, included in the second EU watchlist of emerging pollutants which emphasizes the importance of understanding their occurrence, fate, and monitoring in aquatic environments. Thus, the aim of this study was to develop sensors based on nanostructured thin films deposited on ceramic substrates with gold interdigitated electrodes, to detect azithromycin, clarithromycin, and erythromycin in water matrices (mineral and river water). Impedance spectroscopy was employed as the transducing method for the devices’ electrical signal, producing multivariate datasets which were subsequently analyzed by principal component analysis (PCA). The PCA plots for mineral water demonstrated that ZnO-and TiO2-based sensors produced by DC magnetron sputtering either with 50% or 100% O2 in the sputtering chamber, were able to detect the three macrolides in concentrations between 10−15 M and 10−5 M. In river water, the PCA discrimination presented patterns and trends, between non-doped and doped, and sorting the different concentrations of azithromycin, clarithromycin, and erythromycin. Considering both matrices, by applying the e-tongue concept, sensitivity values of 4.8 ± 0.3, 4.6 ± 0.3, and 4.5 ± 0.3 per decade to azithromycin, clarithromycin, and erythromycin concentration, respectively, were achieved. In all cases, a resolution of 1 × 10−16 M was found near the 10−15 M concentration, the lowest antibiotic concentration measured.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent5500666
dc.identifier.doi10.3390/nano12111858
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 45375091
dc.identifier.otherPURE UUID: 25f7ea84-ea07-469d-8346-1cf6b60b23e4
dc.identifier.otherScopus: 85130927676
dc.identifier.otherPubMed: 35683715
dc.identifier.otherPubMedCentral: PMC9182526
dc.identifier.otherWOS: 000809471100001
dc.identifier.urihttp://hdl.handle.net/10362/143324
dc.identifier.urlhttps://www.scopus.com/pages/publications/85130927676
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantibiotics
dc.subjectelectronic tongue
dc.subjectenvironmental monitoring
dc.subjectimpedance spectroscopy
dc.subjectmetal oxides
dc.subjectnanostructured sensors
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNanostructured Metal Oxide Sensors for Antibiotic Monitoring in Mineral and River Wateren
dc.typejournal article
degois.publication.issue11
degois.publication.titleNanomaterials
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

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