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ADDovenom

2023-12Artigo científico Acesso aberto
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dc.contributor.authorMenzies, Stefanie K.
dc.contributor.authorArinto-Garcia, Raquel
dc.contributor.authorAmorim, Fernanda Gobbi
dc.contributor.authorCardoso, Iara Aimê
dc.contributor.authorAbada, Camille
dc.contributor.authorCrasset, Thomas
dc.contributor.authorDurbesson, Fabien
dc.contributor.authorEdge, Rebecca J.
dc.contributor.authorEl-Kazzi, Priscila
dc.contributor.authorHall, Sophie
dc.contributor.authorRedureau, Damien
dc.contributor.authorStenner, Richard
dc.contributor.authorBoldrini-França, Johara
dc.contributor.authorSun, Huan
dc.contributor.authorRoldão, António
dc.contributor.authorAlves, Paula M.
dc.contributor.authorHarrison, Robert A.
dc.contributor.authorVincentelli, Renaud
dc.contributor.authorBerger, Imre
dc.contributor.authorQuinton, Loïc
dc.contributor.authorCasewell, Nicholas R.
dc.contributor.authorSchaffitzel, Christiane
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-04-02T23:46:55Z
dc.date.available2024-04-02T23:46:55Z
dc.date.issued2023-12
dc.descriptionFunding Information: This work is supported by a Horizon 2020 FET OPEN grant ‘ADDovenom’ (899670). Publisher Copyright: © 2023 by the authors.
dc.description.abstractSnakebite envenoming can be a life-threatening medical emergency that requires prompt medical intervention to neutralise the effects of venom toxins. Each year up to 138,000 people die from snakebites and threefold more victims suffer life-altering disabilities. The current treatment of snakebite relies solely on antivenom—polyclonal antibodies isolated from the plasma of hyperimmunised animals—which is associated with numerous deficiencies. The ADDovenom project seeks to deliver a novel snakebite therapy, through the use of an innovative protein-based scaffold as a next-generation antivenom. The ADDomer is a megadalton-sized, thermostable synthetic nanoparticle derived from the adenovirus penton base protein; it has 60 high-avidity binding sites to neutralise venom toxins. Here, we outline our experimental strategies to achieve this goal using state-of-the-art protein engineering, expression technology and mass spectrometry, as well as in vitro and in vivo venom neutralisation assays. We anticipate that the approaches described here will produce antivenom with unparalleled efficacy, safety and affordability.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2776938
dc.identifier.doi10.3390/toxins15120673
dc.identifier.issn2072-6651
dc.identifier.otherPURE: 83538042
dc.identifier.otherPURE UUID: 52f58ca9-f20f-4b8f-937a-c740be4de1aa
dc.identifier.otherScopus: 85180732967
dc.identifier.otherPubMed: 38133177
dc.identifier.urihttp://hdl.handle.net/10362/165725
dc.identifier.urlhttps://www.scopus.com/pages/publications/85180732967
dc.language.isoeng
dc.peerreviewedyes
dc.subjectADDomer
dc.subjectantivenom
dc.subjectbiologics
dc.subjectsnakebite
dc.subjectvenom
dc.subjectToxicology
dc.subjectHealth, Toxicology and Mutagenesis
dc.titleADDovenomen
dc.title.subtitleThermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenomingen
dc.typejournal article
degois.publication.issue12
degois.publication.titleToxins
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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