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Toxicological Assessment of Cellulose Nanomaterials

2022-10Recensão Acesso aberto
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dc.contributor.authorVital, Nádia
dc.contributor.authorVentura, Célia
dc.contributor.authorKranendonk, Michel
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblMDPI AG
dc.date.accessioned2022-10-24T22:13:39Z
dc.date.available2022-10-24T22:13:39Z
dc.date.issued2022-10
dc.descriptionFunding Information: This work was funded by the Portuguese Fundação para a Ciência e a Tecnologia, I.P. (FCT), through national funds PTDC/SAU-PUB/32587/2017 and PTDC/SAU-PUB/29481/2017. Research was co-funded by UIDB/00009/2020; UIDP/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics, FCT— Fundação para a Ciência e a Tecnologia). N.V. work was funded by Fundação para a Ciência e a Tecnologia, I.P./Ministério da Ciência, Tecnologia, e Ensino Superior (FCT/MCTES) PhD grant 2020.07168.BD. Publisher Copyright: © 2022 by the authors.
dc.description.abstractCellulose nanomaterials (CNMs) have emerged recently as an important group of sustainable bio-based nanomaterials (NMs) with potential applications in multiple sectors, including the food, food packaging, and biomedical fields. The widening of these applications leads to increased human oral exposure to these NMs and, potentially, to adverse health outcomes. Presently, the potential hazards regarding oral exposure to CNMs are insufficiently characterised. There is a need to understand and manage the potential adverse effects that might result from the ingestion of CNMs before products using CNMs reach commercialisation. This work reviews the potential applications of CNMs in the food and biomedical sectors along with the existing toxicological in vitro and in vivo studies, while also identifying current knowledge gaps. Relevant considerations when performing toxicological studies following oral exposure to CNMs are highlighted. An increasing number of studies have been published in the last years, overall showing that ingested CNMs are not toxic to the gastrointestinal tract (GIT), suggestive of the biocompatibility of the majority of the tested CNMs. However, in vitro and in vivo genotoxicity studies, as well as long-term carcinogenic or reproductive toxicity studies, are not yet available. These studies are needed to support a wider use of CNMs in applications that can lead to human oral ingestion, thereby promoting a safe and sustainable-by-design approach.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1813969
dc.identifier.doi10.3390/nano12193375
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 47285340
dc.identifier.otherPURE UUID: bb6f7228-6798-449b-9654-e2fbcbb2f728
dc.identifier.otherScopus: 85139818480
dc.identifier.otherPubMed: 36234501
dc.identifier.urihttp://hdl.handle.net/10362/144962
dc.identifier.urlhttps://www.scopus.com/pages/publications/85139818480
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbiological effects
dc.subjectcellulose nanocrystals
dc.subjectcellulose nanofibres
dc.subjectcellulose nanomaterials
dc.subjectingestion
dc.subjectnanotoxicology
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleToxicological Assessment of Cellulose Nanomaterialsen
dc.title.subtitleOral Exposureen
dc.typereview
degois.publication.issue19
degois.publication.titleNanomaterials
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

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