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Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications

2023-06-24Artigo científico Acesso aberto
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dc.contributor.authorHammami, Imen
dc.contributor.authorGavinho, Sílvia Rodrigues
dc.contributor.authorPádua, Ana Sofia
dc.contributor.authorSá-Nogueira, Isabel
dc.contributor.authorSilva, Jorge Carvalho
dc.contributor.authorBorges, João Paulo
dc.contributor.authorValente, Manuel Almeida
dc.contributor.authorGraça, Manuel Pedro Fernandes
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-09-29T22:22:32Z
dc.date.available2023-09-29T22:22:32Z
dc.date.issued2023-06-24
dc.descriptionThis research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors.
dc.description.abstractImplantology is crucial for restoring aesthetics and masticatory function in oral rehabilitation. Despite its advantages, certain issues, such as bacterial infection, may still arise that hinder osseointegration and result in implant rejection. This work aims to address these challenges by developing a biomaterial for dental implant coating based on 45S5 Bioglass® modified by zirconium insertion. The structural characterization of the glasses, by XRD, showed that the introduction of zirconium in the Bioglass network at a concentration higher than 2 mol% promotes phase separation, with crystal phase formation. Impedance spectroscopy was used, in the frequency range of 102–106 Hz and the temperature range of 200–400 K, to investigate the electrical properties of these Bioglasses, due to their ability to store electrical charges and therefore enhance the osseointegration capacity. The electrical study showed that the presence of crystal phases, in the glass ceramic with 8 mol% of zirconium, led to a significant increase in conductivity. In terms of biological properties, the Bioglasses exhibited an antibacterial effect against Gram-positive and Gram-negative bacteria and did not show cytotoxicity for the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the results of the bioactivity test revealed that within 24 h, a CaP-rich layer began to form on the surface of all the samples. According to our results, the incorporation of 2 mol% of ZrO2 into the Bioglass significantly improves its potential as a coating material for dental implants, enhancing both its antibacterial and osteointegration properties.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17
dc.format.extent6328282
dc.identifier.doi10.3390/ijms241310571
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 72784442
dc.identifier.otherPURE UUID: e0161fca-9cd9-4c0f-90dd-a0bd00faf6c1
dc.identifier.otherScopus: 85164844292
dc.identifier.otherWOS: 001032024700001
dc.identifier.otherPubMed: 37445749
dc.identifier.otherPubMedCentral: PMC10341849
dc.identifier.otherORCID: /0000-0001-9959-4272/work/151367254
dc.identifier.otherORCID: /0000-0002-3996-6545/work/151413848
dc.identifier.urihttp://hdl.handle.net/10362/158489
dc.identifier.urlhttps://www.scopus.com/pages/publications/85164844292
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationCustomization of implants coated with multifunctional biomaterials
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F148233%2F2019/PT
dc.subjectantibacterial properties
dc.subjectbioactivity
dc.subjectBioglass
dc.subjectdielectric properties
dc.subjectimplant coating
dc.subjectosseointegration
dc.subjectzirconium
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleBioactive Glass Modified with Zirconium Incorporation for Dental Implant Applicationsen
dc.title.subtitleFabrication, Structural, Electrical, and Biological Analysisen
dc.typejournal article
degois.publication.issue13
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume24
dspace.entity.typePublication
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardNumberSFRH/BD/148233/2019
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleCustomization of implants coated with multifunctional biomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F148233%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
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