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HBM4EU chromates study

2022-11Artigo científico Acesso aberto
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dc.contributor.authorNdaw, Sophie
dc.contributor.authorLeso, Veruscka
dc.contributor.authorBousoumah, Radia
dc.contributor.authorRémy, Aurélie
dc.contributor.authorBocca, Beatrice
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorHardy, Emilie
dc.contributor.authorJanasik, Beata
dc.contributor.authorvan Nieuwenhuyse, An
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorPoels, Katrien
dc.contributor.authorPorras, Simo P.
dc.contributor.authorRuggieri, Flavia
dc.contributor.authorSantonen, Tiina
dc.contributor.authorSantos, Sílvia Reis
dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorSilva, Maria João
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorIavicoli, Ivo
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblAcademic Press | Elsevier
dc.date.accessioned2022-09-28T22:50:46Z
dc.date.available2022-09-28T22:50:46Z
dc.date.issued2022-11
dc.descriptionFunding Information: This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. Publisher Copyright: © 2022 The Authors
dc.description.abstractOccupational exposures to hexavalent Chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific information on systemic and intracellular bioavailability is necessary. To this aim, concentrations of Cr in red blood cells (RBC-Cr) and in plasma (P–Cr) were analyzed in 345 Cr(VI) exposed workers and 175 controls to understand how these biomarkers may be affected by variable levels of exposure and job procedures. Compared to controls, significantly higher RBC-Cr levels were observed in bath plating and paint application workers, but not in welders, while all the 3 groups had significantly greater P–Cr concentrations. RBC-Cr and P–Cr in chrome platers showed a high correlation with Cr(VI) in inhalable dust, outside respiratory protective equipment (RPE), while such correlation could not be determined in welders. In platers, the use of RPE had a significant impact on the relationship between blood biomarkers and Cr(VI) in inhalable and respirable dust. Low correlations between P–Cr and RBC-Cr may reflect a difference in kinetics. This study showed that Cr-blood-based biomarkers can provide information on how workplace exposure translates into systemic availability of Cr(III) (extracellular, P–Cr) and Cr(VI) (intracellular, RBC-Cr). Further studies are needed to fully appreciate their use in an occupational health and safety context.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1391041
dc.identifier.doi10.1016/j.envres.2022.113758
dc.identifier.issn0013-9351
dc.identifier.otherPURE: 46786494
dc.identifier.otherPURE UUID: fedf3933-0db8-444b-ac8c-649c0932dc2f
dc.identifier.otherScopus: 85133492650
dc.identifier.otherPubMed: 35764127
dc.identifier.otherWOS: 000828167000011
dc.identifier.urihttp://hdl.handle.net/10362/144376
dc.identifier.urlhttps://www.scopus.com/pages/publications/85133492650
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiological monitoring
dc.subjectElectroplating
dc.subjectPlasma chromium
dc.subjectRed blood cells chromium
dc.subjectWelding
dc.subjectWorkplace
dc.subjectBiochemistry
dc.subjectGeneral Environmental Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHBM4EU chromates studyen
dc.title.subtitleusefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposureen
dc.typejournal article
degois.publication.issuePt 1
degois.publication.titleEnvironmental Research
degois.publication.volume214
dspace.entity.typePublication
rcaap.rightsopenAccess

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