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Resistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populations

2024-05Artigo científico Acesso aberto
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dc.contributor.authorSilva, Vanessa
dc.contributor.authorSilva, Adriana
dc.contributor.authorBarbero, Raquel
dc.contributor.authorRomero, Mario
dc.contributor.authordel Campo, Rosa
dc.contributor.authorCaniça, Manuela
dc.contributor.authorCordeiro, Rui
dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorPoeta, Patricia
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblSpringer Science Business Media
dc.date.accessioned2025-02-14T21:20:03Z
dc.date.available2025-02-14T21:20:03Z
dc.date.issued2024-05
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractThis cross-sectional study investigates the methicillin-resistant Staphylococcus aureus (MRSA): its prevalence, antimicrobial resistance, and molecular characteristics in healthy swine populations in central Portugal. A total of 213 samples were collected from pigs on twelve farms, and MRSA prevalence was assessed using selective agar plates and confirmed via molecular methods. Antimicrobial susceptibility testing and whole genome sequencing (WGS) were performed to characterize resistance profiles and genetic determinants. Among the 107 MRSA-positive samples (83.1% prevalence), fattening pigs and breeding sows exhibited notably high carriage rates. The genome of 20 isolates revealed the predominance of the ST398 clonal complex, with diverse spa types identified. Antimicrobial susceptibility testing demonstrated resistance to multiple antimicrobial agents, including penicillin, cefoxitin, and tetracycline. WGS analysis identified a diverse array of resistance genes, highlighting the genetic basis of antimicrobial resistance. Moreover, virulence gene profiling revealed the presence of genes associated with pathogenicity. These findings underscore the significant prevalence of MRSA in swine populations and emphasize the need for enhanced surveillance and control measures to mitigate zoonotic transmission risks. Implementation of prudent antimicrobial use practices and targeted intervention strategies is essential to reducing MRSA prevalence and safeguarding public health. Continued research efforts are warranted to elucidate transmission dynamics and virulence potential, ultimately ensuring food safety and public health protection.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1413725
dc.identifier.doi10.3390/genes15050532
dc.identifier.issn0920-8569
dc.identifier.otherPURE: 106562239
dc.identifier.otherPURE UUID: d7eedb49-eaad-4feb-9ccd-2ab493027249
dc.identifier.otherScopus: 85194219447
dc.identifier.otherPubMed: 38790161
dc.identifier.urihttp://hdl.handle.net/10362/179065
dc.identifier.urlhttps://www.scopus.com/pages/publications/85194219447
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantimicrobial resistance
dc.subjectclonal lineages
dc.subjectMRSA
dc.subjectpigs
dc.subjectvirulence
dc.subjectWGS
dc.subjectGenetics
dc.subjectGenetics(clinical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleResistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populationsen
dc.title.subtitleA Cross-Sectional Studyen
dc.typejournal article
degois.publication.issue5
degois.publication.titleGenes
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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