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Establishment of porous bioceramic hollow and non-hollow microspheres for bone regeneration via ceramic foam methodology

2025Artigo científico Acesso aberto
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dc.contributor.authorRodrigues, Miguel A.
dc.contributor.authorReis, Joana
dc.contributor.authorAbreu, António
dc.contributor.authorLeal, Catarina
dc.contributor.authorFernandes, Susete N.
dc.contributor.authorBorges, João P.
dc.contributor.authorSantos, José D.
dc.contributor.authorLopes, Maria A.
dc.contributor.institutionUNINOVA-Instituto de Desenvolvimento de Novas Tecnologias
dc.contributor.institutionCTS - Centro de Tecnologia e Sistemas
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.pblBlackwell Publishing Ltd
dc.date.accessioned2026-01-20T14:22:00Z
dc.date.available2026-01-20T14:22:00Z
dc.date.issued2025
dc.descriptionPublisher Copyright: © 2025 The Author(s). Journal of the American Ceramic Society published by Wiley Periodicals LLC on behalf of American Ceramic Society.
dc.description.abstractRecent demographic changes and lifestyle disorders have heightened interest in Tissue Engineering and Regenerative Medicine, particularly for bone regeneration therapies addressing musculoskeletal disorders. Effective treatments require biocompatible, bioactive materials for structured healing. This study developed synthetic bone substitutes as porous bioceramic microspheres—hollow (core‒shell) and non-hollow—for bone defect repair and customizable drug delivery. Using ceramic foam injection, Pluronic F-127 acted as a foaming agent within a suspension of hydroxyapatite and sodium alginate. Key parameters such as foaming stability, porosity, mechanical properties, and foam rheology were examined under varying hydroxyapatite concentrations to optimize injectability. The optimized formulation produced uniform hollow (1.2 ± 0.1 mm) and non-hollow (1.8 ± 0.2 mm) microspheres. Characterization via X-ray diffraction confirmed pure-phase hydroxyapatite, while scanning electron microscopy revealed concentric hollow cores, high macroporosity, and interconnected pores exceeding 70%, crucial for osteointegration and drug encapsulation. Both microsphere types achieved over 60% total porosity, enhancing surface area for drug release. This study presents an efficient, cost-effective method for producing customized bioceramic microspheres with high potential for advanced bone tissue regeneration.en
dc.description.versionpublishersversion
dc.description.versioninpress
dc.format.extent2042344
dc.identifier.doi10.1111/jace.70226
dc.identifier.issn0002-7820
dc.identifier.otherPURE: 130207473
dc.identifier.otherPURE UUID: f4051c8c-fdbd-443d-957b-9aff6bb96640
dc.identifier.otherScopus: 105015423312
dc.identifier.urihttp://hdl.handle.net/10362/199547
dc.identifier.urlhttps://www.scopus.com/pages/publications/105015423312
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT//2021.06440.BD/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0037%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50025%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F04540%2F2020/PT
dc.subjectbone regeneration
dc.subjectfoam injection
dc.subjecthollow
dc.subjectnon-hollow
dc.subjectporous bioceramic microspheres
dc.subjectCeramics and Composites
dc.subjectMaterials Chemistry
dc.titleEstablishment of porous bioceramic hollow and non-hollow microspheres for bone regeneration via ceramic foam methodologyen
dc.typejournal article
degois.publication.issue1
degois.publication.titleJournal Of The American Ceramic Society
degois.publication.volume109
dspace.entity.typePublication
rcaap.rightsopenAccess

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