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Insights into Candida Colonization in Intensive Care Unit Patients

2024-06Artigo científico Acesso aberto
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dc.contributor.authorNascimento, Teresa
dc.contributor.authorInácio, João
dc.contributor.authorGuerreiro, Daniela
dc.contributor.authorPatrício, Patrícia
dc.contributor.authorProença, Luís
dc.contributor.authorToscano, Cristina
dc.contributor.authorDiaz, Priscila
dc.contributor.authorBarroso, Helena
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-10-07T22:25:45Z
dc.date.available2024-10-07T22:25:45Z
dc.date.issued2024-06
dc.descriptionFunding Information: The authors thank FCT/MCTES for the financial support to CiiEM (10.54499/UIDB/04585/2020) through national funds. Publisher Copyright: © 2024 by the authors.
dc.description.abstractThe skin mycobiota plays a significant role in infection risk, pathogen transmission, and personalized medicine approaches in intensive care settings. This prospective multicenter study aimed to enhance our understanding of intensive care units’ (ICUs’) Candida colonization dynamics, identify modifiable risk factors, and assess their impact on survival risk. Specimens were taken from 675, 203, and 110 patients at the admission (D1), 5th (D5), and 8th (D8) days of ICU stay, respectively. The patient’s demographic and clinical data were collected. Candida isolates were identified by conventional culture-based microbiology combined with molecular approaches. Overall, colonization was 184/675 (27.3%), 87/203 (42.8%), and 58/110 (52.7%) on D1, D5, and D8, respectively. Candida colonization dynamics were significantly associated with ICU type (odds ratio (OR) = 2.03, 95% CI 1.22–3.39, p = 0.007), respiratory infection (OR = 1.74, 95% CI 1.17–2.58, p = 0.006), hemodialysis (OR = 2.19, 95% CI 1.17–4.10, p = 0.014), COVID-19 (OR = 0.37, 95% CI 0.14–0.99, p = 0.048), and with a poor 3-month outcome (p = 0.008). Skin Candida spp. colonization can be an early warning tool to generate valuable insights into the epidemiology, risk factors, and survival rates of critically ill patients, and should be considered for epidemiological surveillance.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1605657
dc.identifier.doi10.3390/jof10060378
dc.identifier.issn2309-608X
dc.identifier.otherPURE: 100805250
dc.identifier.otherPURE UUID: 4655f0eb-91af-4b8b-9ef3-f9b1718d4613
dc.identifier.otherScopus: 85197145290
dc.identifier.otherWOS: 001257149300001
dc.identifier.otherPubMed: 38921364
dc.identifier.otherPubMedCentral: PMC11204936
dc.identifier.otherORCID: /0000-0001-7367-5007/work/169106705
dc.identifier.urihttp://hdl.handle.net/10362/173132
dc.identifier.urlhttps://www.scopus.com/pages/publications/85197145290
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCandidaspp
dc.subjectcolonization
dc.subjectintensive care unit
dc.subjectprevalence
dc.subjectrisk factors
dc.subjectsurveillance
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectPlant Science
dc.subjectMicrobiology (medical)
dc.titleInsights into Candida Colonization in Intensive Care Unit Patientsen
dc.title.subtitleA Prospective Multicenter Studyen
dc.typejournal article
degois.publication.issue6
degois.publication.titleJournal of Fungi
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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