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Multiple lineages of nematode-Wolbachia symbiosis in supergroup F and convergent loss of bacterioferritin in filarial Wolbachia

2023-05Artigo científico Acesso aberto
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dc.contributor.authorSinha, Amit
dc.contributor.authorLi, Zhiru
dc.contributor.authorPoole, Catherine B
dc.contributor.authorEttwiller, Laurence
dc.contributor.authorLima, Nathália F
dc.contributor.authorFerreira, Marcelo U
dc.contributor.authorFombad, Fanny F
dc.contributor.authorWanji, Samuel
dc.contributor.authorCarlow, Clotilde K S
dc.contributor.institutionIndividual Health Care (IHC)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblOxford University Press
dc.date.accessioned2023-11-21T22:21:14Z
dc.date.available2023-11-21T22:21:14Z
dc.date.issued2023-05
dc.description© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.
dc.description.abstractThe intracellular endosymbiotic proteobacteria Wolbachia have evolved across the phyla nematoda and arthropoda. In Wolbachia phylogeny, supergroup F is the only clade known so far with members from both arthropod and filarial nematode hosts and therefore can provide unique insights into their evolution and biology. In this study, 4 new supergroup F Wolbachia genomes have been assembled using a metagenomic assembly and binning approach, wMoz and wMpe from the human filarial parasites Mansonella ozzardi and Mansonella perstans, and wOcae and wMoviF from the blue mason bee Osmia caerulescens and the sheep ked Melophagus ovinus respectively. A comprehensive phylogenomic analysis revealed two distinct lineages of filarial Wolbachia in supergroup F, indicating multiple horizontal transfer events between arthropod and nematode hosts. The analysis also reveals that the evolution of Wolbachia-filaria symbioses is accompanied by a convergent pseudogenization and loss of the bacterioferritin gene, a phenomenon found to be shared by all filarial Wolbachia, even those outside supergroup F. These observations indicate that differences in heme metabolism might be a key feature distinguishing filarial and arthropod Wolbachia. The new genomes provide a valuable resource for further studies on symbiosis, evolution, and the discovery of new antibiotics to treat mansonellosis.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent21
dc.format.extent1481452
dc.identifier.doi10.1093/gbe/evad073
dc.identifier.issn1759-6653
dc.identifier.otherPURE: 63157656
dc.identifier.otherPURE UUID: 71dd2f5b-235a-4f56-b173-6ecaed2481e7
dc.identifier.otherPubMed: 37154102
dc.identifier.otherPubMedCentral: PMC10195089
dc.identifier.otherWOS: 000991892600005
dc.identifier.otherScopus: 85161270052
dc.identifier.otherORCID: /0000-0002-5293-9090/work/151380513
dc.identifier.urihttp://hdl.handle.net/10362/160252
dc.identifier.urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=nova_api&SrcAuth=WosAPI&KeyUT=WOS:000991892600005&DestLinkType=FullRecord&DestApp=WOS
dc.language.isoeng
dc.peerreviewedyes
dc.subjectWolbachia
dc.subjectfilaria
dc.subjectevolution
dc.subjectbacterioferritin
dc.subjectheme
dc.subjectphylogenomics
dc.subjectQR Microbiology
dc.subjectRA Public aspects of medicine
dc.subjectEpidemiology
dc.subjectInfectious Diseases
dc.subjectMicrobiology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMultiple lineages of nematode-Wolbachia symbiosis in supergroup F and convergent loss of bacterioferritin in filarial Wolbachiaen
dc.typejournal article
degois.publication.issue5
degois.publication.titleGenome Biology and Evolution
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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