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The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis

2019-07-26Artigo científico Acesso aberto
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dc.contributor.authorLozza, Laura
dc.contributor.authorMoura-Alves, Pedro
dc.contributor.authorDomaszewska, Teresa
dc.contributor.authorLage Crespo, Carolina
dc.contributor.authorStreata, Ioana
dc.contributor.authorKreuchwig, Annika
dc.contributor.authorPuyskens, Andreas
dc.contributor.authorBechtle, Marina
dc.contributor.authorKlemm, Marion
dc.contributor.authorZedler, Ulrike
dc.contributor.authorSilviu Ungureanu, Bogdan
dc.contributor.authorGuhlich-Bornhof, Ute
dc.contributor.authorKoehler, Anne Britta
dc.contributor.authorStäber, Manuela
dc.contributor.authorMollenkopf, Hans Joachim
dc.contributor.authorHurwitz, Robert
dc.contributor.authorFurkert, Jens
dc.contributor.authorKrause, Gerd
dc.contributor.authorWeiner, January
dc.contributor.authorJacinto, António
dc.contributor.authorJacinto, Antonio
dc.contributor.authorMihai, Ioana
dc.contributor.authorLeite-de-Moraes, Maria
dc.contributor.authorSiebenhaar, Frank
dc.contributor.authorMaurer, Marcus
dc.contributor.authorKaufmann, Stefan H.E.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2019-09-02T22:29:52Z
dc.date.available2019-09-02T22:29:52Z
dc.date.issued2019-07-26
dc.description.abstractAs a first host barrier, the skin is constantly exposed to environmental insults that perturb its integrity. Tight regulation of skin homeostasis is largely controlled by the aryl hydrocarbon receptor (AhR). Here, we demonstrate that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo. In human keratinocytes and epidermis equivalents, Lawsone exposure enhances the production of late epidermal proteins, impacts keratinocyte differentiation and proliferation, and regulates skin inflammation. To determine the potential use of Lawsone for therapeutic application, we harnessed human, murine and zebrafish models. In skin regeneration models, Lawsone interferes with physiological tissue regeneration and inhibits wound healing. Conversely, in a human acute dermatitis model, topical application of a Lawsone-containing cream ameliorates skin irritation. Altogether, our study reveals how a widely used natural plant pigment is sensed by the host receptor AhR, and how the physiopathological context determines beneficial and detrimental outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2915426
dc.identifier.doi10.1038/s41598-019-47350-x
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 14543776
dc.identifier.otherPURE UUID: 58ca9367-1702-4cb7-a3c1-89316c02a609
dc.identifier.otherScopus: 85069718136
dc.identifier.otherPubMed: 31350436
dc.identifier.otherORCID: /0000-0002-4193-6089/work/63883977
dc.identifier.otherWOS: 000477698600036
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85069718136&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85069718136
dc.language.isoeng
dc.peerreviewedyes
dc.subjectKERATINOCYTES
dc.subjectEXPRESSION
dc.subjectDIOXIN
dc.subjectAHR
dc.subjectDIFFERENTIATION
dc.subject2,3,7,8
dc.subjectTETRACHLORODIBENZO-PARA-DIOXIN
dc.subjectIDENTIFICATION
dc.subjectDERMATITIS
dc.subjectINDUCTION
dc.subjectTOXICITY
dc.subjectGeneral
dc.titleThe Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasisen
dc.typejournal article
degois.publication.issue1
degois.publication.titleScientific Reports
degois.publication.volume9
dspace.entity.typePublication
person.familyNameJacinto
person.givenNameAntonio
person.identifier.ciencia-idDF15-1DEB-A48C
person.identifier.orcid0000-0002-4193-6089
person.identifier.ridF-5729-2013
person.identifier.scopus-author-id55880355900
rcaap.rightsopenAccess
relation.isAuthorOfPublication37ff3a19-e7d7-4c9f-af75-fade2f9aa9d1
relation.isAuthorOfPublication.latestForDiscovery37ff3a19-e7d7-4c9f-af75-fade2f9aa9d1

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