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Non-pharmacological interventions modulating immune response in Parkinson's disease

2026-10Recensão Acesso aberto
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dc.contributor.authorPirovano, Elenamaria
dc.contributor.authorSilva, Inês P.
dc.contributor.authorCamacho, Marta
dc.contributor.authorÇanak, Asuman
dc.contributor.authorAktas, Busra
dc.contributor.authorCrompton, David
dc.contributor.authorGökçe, Evrim
dc.contributor.authorTan, Fu Miao
dc.contributor.authorMarino, Franca
dc.contributor.authorDomingos, Josefa
dc.contributor.authorAlmeida, Mafalda F.
dc.contributor.authorComi, Cristoforo
dc.contributor.authorDragic, Milorad
dc.contributor.authorFigueira, Inês
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionNOVA Institute for Medical Systems Biology
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblElsevier Science B.V., Amsterdam.
dc.date.accessioned2026-07-27T09:42:01Z
dc.date.available2026-07-27T09:42:01Z
dc.date.issued2026-10
dc.descriptionPublisher Copyright: © 2026 The Authors.
dc.description.abstractParkinson's disease (PD) imposes a growing socioeconomic burden due to its increasing prevalence and lack of a cure. Existing treatment options primarily manage motor and nonmotor symptoms but do not halt or slow disease progression, underscoring the urgent need for more effective and preventative strategies. Growing evidence suggests a strong link between immune system dysfunction, chronic inflammation, and the early pathogenesis of Parkinson's disease, often occurring years before the onset of motor symptoms, thereby indicating a critical window for early intervention. In this review, we examine current evidence on non-pharmacological approaches such as dietary changes, physical activity, and gut microbiome regulation, focusing on their potential to modulate both peripheral and central immune responses, thereby influencing the progression of PD. Besides being complementary to standard pharmacological treatments, these approaches not only reduce systemic inflammation but may also help delay, prevent, or improve clinical management of PD by targeting and modulating its immunological foundations.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2341575
dc.identifier.doi10.1016/j.neuint.2026.106211
dc.identifier.issn0197-0186
dc.identifier.otherPURE: 168911858
dc.identifier.otherPURE UUID: 5bed77ab-6c3e-4203-9b6c-147a8f31a056
dc.identifier.otherScopus: 105044074520
dc.identifier.urihttp://hdl.handle.net/10362/204852
dc.identifier.urlhttps://www.scopus.com/pages/publications/105044074520
dc.language.isoeng
dc.peerreviewedyes
dc.subjectDiet
dc.subjectExercise
dc.subjectImmune response
dc.subjectNeuroinflammation
dc.subjectParkinson's disease
dc.subjectSystemic inflammation
dc.subjectCellular and Molecular Neuroscience
dc.subjectCell Biology
dc.titleNon-pharmacological interventions modulating immune response in Parkinson's diseaseen
dc.title.subtitlewhere do we stand for future preventive approachesen
dc.typereview
degois.publication.titleNeurochemistry International
degois.publication.volume199
dspace.entity.typePublication
rcaap.rightsopenAccess

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NMS: CHRC - Artigos em revista internacional com arbitragem científica