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A receptor-mediated landscape of druggable and targeted nanomaterials for gliomas

2023-06Recensão Acesso aberto
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dc.contributor.authorDi Filippo, Leonardo Delello
dc.contributor.authorde Carvalho, Suzana Gonçalves
dc.contributor.authorDuarte, Jonatas Lobato
dc.contributor.authorLuiz, Marcela Tavares
dc.contributor.authorPaes Dutra, Jessyca Aparecida
dc.contributor.authorde Paula, Geanne Aparecida
dc.contributor.authorChorilli, Marlus
dc.contributor.authorConde, João
dc.contributor.authorConde, João
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblElsevier BV
dc.date.accessioned2023-06-09T22:22:30Z
dc.date.available2023-06-09T22:22:30Z
dc.date.issued2023-06
dc.description2022/06224-7 form Fundação de Amparo à Pesquisa do Estado de São Paulo . Publisher Copyright: © 2023 The Authors
dc.description.abstractGliomas are the most common type of brain cancer, and among them, glioblastoma multiforme (GBM) is the most prevalent (about 60% of cases) and the most aggressive type of primary brain tumor. The treatment of GBM is a major challenge due to the pathophysiological characteristics of the disease, such as the presence of the blood-brain barrier (BBB), which prevents and regulates the passage of substances from the bloodstream to the brain parenchyma, making many of the chemotherapeutics currently available not able to reach the brain in therapeutic concentrations, accumulating in non-target organs, and causing considerable adverse effects for the patient. In this scenario, nanocarriers emerge as tools capable of improving the brain bioavailability of chemotherapeutics, in addition to improving their biodistribution and enhancing their uptake in GBM cells. This is possible due to its nanometric size and surface modification strategies, which can actively target nanocarriers to elements overexpressed by GBM cells (such as transmembrane receptors) related to aggressive development, drug resistance, and poor prognosis. In this review, an overview of the most frequently overexpressed receptors in GBM cells and possible approaches to chemotherapeutic delivery and active targeting using nanocarriers will be presented.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3295517
dc.identifier.doi10.1016/j.mtbio.2023.100671
dc.identifier.issn2590-0064
dc.identifier.otherPURE: 63277317
dc.identifier.otherPURE UUID: 1a9166e6-1a82-4ab5-ba5c-acd4b15c0eea
dc.identifier.otherScopus: 85160439097
dc.identifier.otherPubMed: 37273792
dc.identifier.urihttp://hdl.handle.net/10362/153784
dc.identifier.urlhttps://www.scopus.com/pages/publications/85160439097
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: J.C. acknowledges the European Research Council - ERC Starting Grant 848325 for financial support. L.D.D.F and M.C. acknowledge FAPESP grants
dc.relation2020/12622-0 and
dc.subjectBrain cancer
dc.subjectDrug delivery
dc.subjectGlioma
dc.subjectMolecular machinery
dc.subjectNanomedicine
dc.subjectTarget delivery
dc.subjectBiotechnology
dc.subjectBioengineering
dc.subjectBiomaterials
dc.subjectBiomedical Engineering
dc.subjectMolecular Biology
dc.subjectCell Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleA receptor-mediated landscape of druggable and targeted nanomaterials for gliomasen
dc.typereview
degois.publication.titleMaterials Today Bio
degois.publication.volume20
dspace.entity.typePublication
person.familyNameConde
person.givenNameJoão
person.identifier807432
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.orcid0000-0001-8422-6792
person.identifier.ridF-2231-2011
person.identifier.scopus-author-id56992468300
rcaap.rightsopenAccess
relation.isAuthorOfPublication33ca4178-1b25-4b5e-ae16-b2500abe4c58
relation.isAuthorOfPublication.latestForDiscovery33ca4178-1b25-4b5e-ae16-b2500abe4c58

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