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Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study

2022-07-22Artigo científico Acesso aberto
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dc.contributor.authorPolok, Kamil
dc.contributor.authorFronczek, Jakub
dc.contributor.authorArtigas, Antonio
dc.contributor.authorFlaatten, Hans
dc.contributor.authorGuidet, Bertrand
dc.contributor.authorDe Lange, Dylan W.
dc.contributor.authorFjølner, Jesper
dc.contributor.authorLeaver, Susannah
dc.contributor.authorBeil, Michael
dc.contributor.authorSviri, Sigal
dc.contributor.authorBruno, Raphael Romano
dc.contributor.authorWernly, Bernhard
dc.contributor.authorBollen Pinto, Bernardo
dc.contributor.authorSchefold, Joerg C.
dc.contributor.authorStudzińska, Dorota
dc.contributor.authorJoannidis, Michael
dc.contributor.authorOeyen, Sandra
dc.contributor.authorMarsh, Brian
dc.contributor.authorAndersen, Finn H.
dc.contributor.authorMoreno, Rui
dc.contributor.authorCecconi, Maurizio
dc.contributor.authorJung, Christian
dc.contributor.authorSzczeklik, Wojciech
dc.contributor.authorEller, Philipp
dc.contributor.authorMesotten, Dieter
dc.contributor.authorReper, Pascal
dc.contributor.authorSwinnen, Walter
dc.contributor.authorBrix, Helene
dc.contributor.authorBrushoej, Jens
dc.contributor.authorVillefrance, Maja
dc.contributor.authorNedergaard, Helene Korvenius
dc.contributor.authorBjerregaard, Anders Thais
dc.contributor.authorBalleby, Ida Riise
dc.contributor.authorAndersen, Kasper
dc.contributor.authorHansen, Maria Aagaard
dc.contributor.authorUhrenholt, Stine
dc.contributor.authorBundgaard, Helle
dc.contributor.authorHussein, Aliae A.R.Mohamed
dc.contributor.authorSalah, Rehab
dc.contributor.authorAli, Yasmin Khairy Nasr Eldin Mohamed
dc.contributor.authorWassim, Kyrillos
dc.contributor.authorElgazzar, Yumna A.
dc.contributor.authorTharwat, Samar
dc.contributor.authorAzzam, Ahmed Y.
dc.contributor.authorhabib, Ayman abdelmawgoad
dc.contributor.authorAbosheaishaa, Hazem Maarouf
dc.contributor.authorAzab, Mohammed A.
dc.contributor.authorGalbois, Arnaud
dc.contributor.authorCharron, Cyril
dc.contributor.authorGuerot, Emmanuel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2022-09-06T22:37:51Z
dc.date.available2022-09-06T22:37:51Z
dc.date.issued2022-07-22
dc.descriptionFunding Information: COVIP study did not have any funding. Publication of this article was funded by the Priority Research Area qLife under the program “Excellence Initiative – Research University” at the Jagiellonian University in Krakow (06/IDUB/2019/94). Publisher Copyright: © 2022, The Author(s).
dc.description.abstractBackground: Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. We aimed to evaluate the use of NIV in Europe and factors associated with outcomes of patients treated with NIV. Methods: This is a substudy of COVIP study—an international prospective observational study enrolling patients aged ≥ 70 years with confirmed COVID-19 treated in ICU. We enrolled patients in 156 ICUs across 15 European countries between March 2020 and April 2021.The primary endpoint was 30-day mortality. Results: Cohort included 3074 patients, most of whom were male (2197/3074, 71.4%) at the mean age of 75.7 years (SD 4.6). NIV frequency was 25.7% and varied from 1.1 to 62.0% between participating countries. Primary NIV failure, defined as need for endotracheal intubation or death within 30 days since ICU admission, occurred in 470/629 (74.7%) of patients. Factors associated with increased NIV failure risk were higher Sequential Organ Failure Assessment (SOFA) score (OR 3.73, 95% CI 2.36–5.90) and Clinical Frailty Scale (CFS) on admission (OR 1.46, 95% CI 1.06–2.00). Patients initially treated with NIV (n = 630) lived for 1.36 fewer days (95% CI − 2.27 to − 0.46 days) compared to primary IMV group (n = 1876). Conclusions: Frequency of NIV use varies across European countries. Higher severity of illness and more severe frailty were associated with a risk of NIV failure among critically ill older adults with COVID-19. Primary IMV was associated with better outcomes than primary NIV. Clinical Trial RegistrationNCT04321265, registered 19 March 2020, https://clinicaltrials.gov.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1036660
dc.identifier.doi10.1186/s13054-022-04082-1
dc.identifier.issn1364-8535
dc.identifier.otherPURE: 46124537
dc.identifier.otherPURE UUID: 8d3f9117-4134-4428-9949-9fb40b3758e7
dc.identifier.otherScopus: 85135202514
dc.identifier.otherPubMed: 35869557
dc.identifier.otherWOS: 000829031000001
dc.identifier.urihttp://hdl.handle.net/10362/143540
dc.identifier.urlhttps://www.scopus.com/pages/publications/85135202514
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCOVID-19
dc.subjectElderly
dc.subjectFrailty
dc.subjectIntensive care unit
dc.subjectNoninvasive ventilation
dc.subjectCritical Care and Intensive Care Medicine
dc.titleNoninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort studyen
dc.typejournal article
degois.publication.issue1
degois.publication.titleCritical Care
degois.publication.volume26
dspace.entity.typePublication
rcaap.rightsopenAccess

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