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Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

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dc.contributor.authorDirven, Hubert
dc.contributor.authorBogusz, Aleksandra
dc.contributor.authorBouwmeester, Hans
dc.contributor.authorBusch, Mathias
dc.contributor.authorDuflos, Guillaume
dc.contributor.authorEriksen, Gunnar S.
dc.contributor.authorFardilha, Margarida
dc.contributor.authorFlores-Gomez, Daniela
dc.contributor.authorFranko, Nina
dc.contributor.authorGaté, Laurent
dc.contributor.authorGuichard, Yves
dc.contributor.authorSilva, Maria João
dc.contributor.authorKamstra, Jorke H.
dc.contributor.authorKasiotis, Konstantinos M.
dc.contributor.authorKim, Sunmi
dc.contributor.authorKim, Young Jun
dc.contributor.authorKim, Youngsam
dc.contributor.authorvan der Koogh, Elise
dc.contributor.authorLoureiro, Susana
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMachera, Kyriaki
dc.contributor.authorPieters, Raymond H.H.
dc.contributor.authorSpyropoulou, Anastasia
dc.contributor.authorTzanetou, Evangelia N.
dc.contributor.authorMalheiro, Catarina
dc.contributor.authorRavnjak, Tim
dc.contributor.authorRepetto, Guillermo
dc.contributor.authorRivière, Gilles
dc.contributor.authorRyu, Chang Seon
dc.contributor.authorPapadopoulou, Evgenia Anna
dc.contributor.authorAliferis, Konstantinos A.
dc.contributor.authorSolhaug, Anita
dc.contributor.authorDolenc, Marija Sollner
dc.contributor.authorŠtampar, Martina
dc.contributor.authorTavares, Ana M.
dc.contributor.authorTollefsen, Knut Erik
dc.contributor.authorVentura, Célia
dc.contributor.authorWalkowiak, Radoslaw
dc.contributor.authorZobl, Walter
dc.contributor.authorŽegura, Bojana
dc.contributor.authorSnapkow, Igor
dc.contributor.authorHerzke, Dorte
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2026-01-22T10:52:02Z
dc.date.available2026-01-22T10:52:02Z
dc.date.issued2025
dc.descriptionPublisher Copyright: Copyright © 2025 Dirven, Bogusz, Bouwmeester, Busch, Duflos, Eriksen, Fardilha, Flores-Gomez, Franko, Gaté, Guichard, Silva, Kamstra, Kasiotis, Kim, Kim, Kim, van der Koogh, Loureiro, Louro, Machera, Pieters, Spyropoulou, Tzanetou, Malheiro, Ravnjak, Repetto, Rivière, Ryu, Papadopoulou, Aliferis, Solhaug, Dolenc, Štampar, Tavares, Tollefsen, Ventura, Walkowiak, Zobl, Žegura, Snapkow and Herzke.
dc.description.abstractA recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the environment. To refine the risk assessment of these leachable chemicals, additional hazard data are needed. The PlasticLeach project within the EU co-funded Partnership for the Assessment of Risks from Chemicals (PARC) aims to address this data gap by screening several plastic products in daily use. Leachates will be prepared from a number of these plastic items, and these chemical mixtures will be further tested using several test guideline compliant assays and New Approach Methodologies covering both human health and environmental endpoints. The most toxic leachates will be characterized using a non-targeted analysis pipeline to identify chemicals in the leachate. When single chemicals of concern are identified, these will be further tested to determine hazardous properties and identify the respective potency factors to better understand their specific hazard profiles. A tiered approach for hazard testing will be followed. The experimental work will be complemented by in silico toxicological profiling, using publicly available toxicity databases and tools, including Artificial Intelligence tools that cover both human and environmental endpoints. A comprehensive array of endpoints, including cytotoxicity, endocrine disruption, genotoxicity, immunotoxicity, reproductive toxicity and effects related to ecotoxicity will be evaluated. In this paper, we outline the plastic products to be tested and the battery of assays that will be used to identify hazards relevant to both human health and the environment. Data generated from in silico, in vitro, and in vivo approaches will be reported using standardized formats, stored within a centralized repository, and harmonized to adhere to the FAIR data principles (Findable, Accessible, Interoperable, and Reusable). This integrated strategy will not only advance our understanding of the risks associated with plastic-derived chemicals but will also provide critical support for regulatory decision-making and facilitate the development of safer, and more ecofriendly plastic materials in the future.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1482854
dc.identifier.doi10.3389/ftox.2025.1719035
dc.identifier.issn2673-3080
dc.identifier.otherPURE: 149010698
dc.identifier.otherPURE UUID: 5b145c17-5c88-49b2-8fd6-6968cda35dab
dc.identifier.otherScopus: 105024580981
dc.identifier.otherPubMed: 41393343
dc.identifier.urihttp://hdl.handle.net/10362/199638
dc.identifier.urlhttps://www.scopus.com/pages/publications/105024580981
dc.language.isoeng
dc.peerreviewedyes
dc.subjectchemicals
dc.subjecthazard assessment
dc.subjectleachables
dc.subjectnew approach methodologies
dc.subjectPARC
dc.subjectplastics
dc.subjectrisk assessment
dc.subjecttoxicity
dc.subjectToxicology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHazard identification and characterization of leachable chemicals from plastic products – a new PARC projecten
dc.typejournal article
degois.publication.titleFrontiers in Toxicology
degois.publication.volume7
dspace.entity.typePublication
rcaap.rightsopenAccess

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