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PD-1 Expression in Endometriosis

2025-12Artigo científico Acesso aberto
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dc.contributor.authorReis, José Lourenço
dc.contributor.authorMartins, Catarina
dc.contributor.authorÂngelo-Dias, Miguel
dc.contributor.authorRosa, Natacha Nurdine
dc.contributor.authorBorrego, Luís Miguel
dc.contributor.authorLima, Jorge
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2026-01-14T15:55:04Z
dc.date.available2026-01-14T15:55:04Z
dc.date.issued2025-12
dc.descriptionPublisher Copyright: © 2025 by the authors.
dc.description.abstractBackground: Endometriosis, believed by many to be rooted in immunology, is a chronic disease. Upregulation of programmed cell death protein 1 (PD-1) in immune cells may compromise their defensive function, a mechanism demonstrated in the context of cancer spread. This study aims to explore the potential involvement of PD-1 in the pathophysiology and progression of endometriosis. A total of 62 patients who underwent laparoscopic surgery were analyzed, with 47 diagnosed with endometriosis and 15 serving as controls. We collected peritoneal fluid and peripheral blood samples during surgery and examined them using flow cytometry. Using a panel of monoclonal antibodies, the samples were stained and the expression of PD-1 in immune cells was evaluated. Results: We observed a statistically significant rise in the percentage of the CD56+ CD16+ NK cell subset expressing PD-1 within the peritoneal fluid of endometriosis patients compared to the control group (p = 0.021). Similarly, we found that PD-1 expression on immune cells significantly differed based on factors such as body mass index and smoking habits. Moreover, peritoneal subsets of PD-1+ T and NK cells showed an increase in patients presenting symptomatic endometriosis and those with more widespread disease. Conclusions: Our evaluation of the inhibitory PD-1 receptor has strengthened the potential connection between immune escape mechanisms often seen in cancer cells and those in endometriotic cells. This concept could pave the way for future research in the field of immunomodulation and endometriosis.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2893600
dc.identifier.doi10.3390/immuno5040049
dc.identifier.issn2673-5601
dc.identifier.otherPURE: 148988362
dc.identifier.otherPURE UUID: 2f1a244b-5d2a-461a-a859-da1e2c71f840
dc.identifier.otherScopus: 105025714360
dc.identifier.otherORCID: /0000-0003-0353-0421/work/202237336
dc.identifier.otherORCID: /0000-0003-4708-438X/work/202237738
dc.identifier.otherORCID: /0000-0001-9933-4075/work/206216936
dc.identifier.otherWOS: 001646673300001
dc.identifier.urihttp://hdl.handle.net/10362/199055
dc.identifier.urlhttps://www.scopus.com/pages/publications/105025714360
dc.language.isoeng
dc.peerreviewedyes
dc.subjectendometriosis
dc.subjectimmune receptors
dc.subjectNK cells
dc.subjectPD-1
dc.subjectT cells
dc.subjectMedicine (miscellaneous)
dc.subjectImmunology
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePD-1 Expression in Endometriosisen
dc.typejournal article
degois.publication.issue4
degois.publication.titleImmuno
degois.publication.volume5
dspace.entity.typePublication
rcaap.rightsopenAccess

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