Logo do repositório
 
Publicação

Long-term effects of dietary protein and carbohydrate quality on prediabetes remission

2026-01Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorZhu, Ruixin
dc.contributor.authorGuo, Jie
dc.contributor.authorHuttunen-Lenz, Maija
dc.contributor.authorSilvestre, Marta
dc.contributor.authorStratton, Gareth
dc.contributor.authorMacdonald, Ian A.
dc.contributor.authorHandjieva-Darlenska, Teodora
dc.contributor.authorHandjiev, Svetoslav
dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorPoppitt, Sally D.
dc.contributor.authorFogelholm, Mikael
dc.contributor.authorMartinez-Urbistondo, Diego
dc.contributor.authorMartinez, J. Alfredo
dc.contributor.authorRaben, Anne
dc.contributor.authorBrand-Miller, Jennie
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.pblSpringer
dc.date.accessioned2025-11-11T22:05:07Z
dc.date.available2025-11-11T22:05:07Z
dc.date.issued2026-01
dc.descriptionPublisher Copyright: © The Author(s) 2025.
dc.description.abstractAims/hypothesis: Recent studies advocate prediabetes remission as a goal in diabetes prevention, but the optimal dietary composition for prediabetes remission over the long term is unknown. We aimed to examine the long-term effects on prediabetes remission of a prudent diet with moderate protein and a moderate glycaemic index (GI) (akin to general dietary guidelines) vs a high-protein, low-GI diet. Methods: This study is a secondary analysis of PREVIEW, which is a 3 year, multicentre, parallel, randomised trial. Adults with overweight/obesity (BMI ≥ 25 and <30 kg/m2 or BMI ≥ 30 kg/m2, respectively) and prediabetes (fasting glucose 5.6–6.9 mmol/l and/or 2 h glucose 7.8–11.0 mmol/l determined using an OGTT) were recruited. Eligible participants underwent an 8-week rapid weight loss programme comprising a low-energy diet, followed by a 3 year weight maintenance phase comprising lifestyle intervention. At baseline, participants were randomly assigned to a high-protein (25% of energy from protein), low-GI (GI<50) diet, or a prudent diet with moderate protein (15% of energy from protein) and moderate GI (GI>56). The primary outcome of the current analysis was the number of participants who achieved prediabetes remission (i.e. a return to normal fasting glucose and normal glucose tolerance) at 1 year or 3 years. Secondary outcomes were changes in body weight and composition over 3 years (continuous variables) and maintenance of a ≥8% weight loss target (binary variable). Modified intention-to-treat analyses were performed on all participants who received the dietary intervention (n=1856). Risk ratios and 95% CI for prediabetes remission and maintaining the weight loss target in each diet group were estimated using multilevel modified Poisson regression adjusted for age and sex. Linear mixed models were used to estimate the dietary effects on changes in body weight and composition. Results: The moderate-protein, moderate-GI group (n=923) had a higher rate of remission than the high-protein, low-GI group (n=933) at both 1 year (rate of remission 26.3% vs 20.7%; RR 1.26; 95% CI 1.04, 1.53; p=0.025) and 3 years (20.6% vs 15.5%; RR 1.26; 95% CI 1.06, 1.50; p=0.015). However, body weight and composition changes were similar for participants on the moderate-protein, moderate-GI vs high-protein, low-GI diet at 1 year (54.0% vs 57.3% of participants met the weight loss maintenance target [≥8% of initial body weight]; p=0.215) and 3 years (31.4% vs 30.4%, respectively; p=0.793). The differences in remission rates of the two dietary patterns were independent of body weight and composition changes. Conclusions/interpretation: Following rapid weight loss, a prudent diet with moderate protein and moderate GI was more effective for long-term prediabetes remission than a high-protein, low-GI diet, irrespective of weight change. Trial registration: ClinicalTrials.goven
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1540354
dc.identifier.doi10.1007/s00125-025-06560-x
dc.identifier.issn0012-186X
dc.identifier.otherPURE: 135140405
dc.identifier.otherPURE UUID: 9cea4500-19c3-4d3b-bac1-0aa2a84615dd
dc.identifier.otherScopus: 105018837611
dc.identifier.otherPubMed: 41094026
dc.identifier.otherORCID: /0000-0001-9327-2897/work/196676758
dc.identifier.urihttp://hdl.handle.net/10362/190552
dc.identifier.urlhttps://www.scopus.com/pages/publications/105018837611
dc.language.isoeng
dc.peerreviewedyes
dc.subjectDiabetes prevention
dc.subjectDiet
dc.subjectDietary composition
dc.subjectGlycaemic index
dc.subjectGlycaemic load
dc.subjectNormoglycaemia
dc.subjectNutrition
dc.subjectInternal Medicine
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectSDG 3 - Good Health and Well-being
dc.titleLong-term effects of dietary protein and carbohydrate quality on prediabetes remissionen
dc.title.subtitleresults from the PREVIEW randomised multinational diabetes prevention trialen
dc.typejournal article
degois.publication.firstPage81
degois.publication.issue1
degois.publication.lastPage92
degois.publication.titleDiabetologia
degois.publication.volume69
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
s00125-025-06560-x.pdf
Tamanho:
1.47 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CINTESIS - Artigos em revista internacional com arbitragem científica