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Extracellular vesicle proteome in prostate cancer

2021-12-01Recensão Acesso aberto
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dc.contributor.authorBernardino, Rui M.
dc.contributor.authorLeão, Ricardo
dc.contributor.authorHenrique, Rui
dc.contributor.authorPinheiro, Luis Campos
dc.contributor.authorKumar, Prashant
dc.contributor.authorSuravajhala, Prashanth
dc.contributor.authorBeck, Hans Christian
dc.contributor.authorCarvalho, Ana Sofia
dc.contributor.authorMatthiesen, Rune
dc.contributor.authorMatthiesen, Rune
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-01-15T03:30:21Z
dc.date.available2022-01-15T03:30:21Z
dc.date.issued2021-12-01
dc.descriptionFunding Information: Funding: R.M. is supported by Fundação para a Ciência e a Tecnologia (CEEC position, 2019–2025 investigator). This article is a result of the projects (iNOVA4Health—UIDB/04462/2020), supported by Lisboa Portugal Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work is also funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects number PTDC/BTM-TEC/30087/2017 and PTDC/BTM-TEC/30088/2017. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractMolecular diagnostics based on discovery research holds the promise of improving screening methods for prostate cancer (PCa). Furthermore, the congregated information prompts the question whether the urinary extracellular vesicles (uEV) proteome has been thoroughly ex-plored, especially at the proteome level. In fact, most extracellular vesicles (EV) based biomarker studies have mainly targeted plasma or serum. Therefore, in this study, we aim to inquire about possible strategies for urinary biomarker discovery particularly focused on the proteome of urine EVs. Proteomics data deposited in the PRIDE archive were reanalyzed to target identifications of potential PCa markers. Network analysis of the markers proposed by different prostate cancer studies revealed moderate overlap. The recent throughput improvements in mass spectrometry together with the network analysis performed in this study, suggest that a larger standardized cohort may provide potential biomarkers that are able to fully characterize the heterogeneity of PCa. According to our analysis PCa studies based on urinary EV proteome presents higher protein coverage compared to plasma, plasma EV, and voided urine proteome. This together with a direct interaction of the prostate gland and urethra makes uEVs an attractive option for protein biomarker studies. In addition, urinary proteome based PCa studies must also evaluate samples from bladder and renal cancers to assess specificity for PCa.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3277460
dc.identifier.doi10.3390/ijms222413605
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 35620864
dc.identifier.otherPURE UUID: 1fb8e93d-946c-475e-9ac1-56739e8c0bed
dc.identifier.otherScopus: 85121318366
dc.identifier.otherWOS: 000738622700001
dc.identifier.urihttp://hdl.handle.net/10362/130894
dc.identifier.urlhttps://www.scopus.com/pages/publications/85121318366
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiomarkers
dc.subjectExtracellular vesicles (EVs)
dc.subjectProstate cancer
dc.subjectProteomics
dc.subjectUrine extracellular vesicles (uEVs)
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleExtracellular vesicle proteome in prostate canceren
dc.title.subtitleA comparative analysis of mass spectrometry studiesen
dc.typereview
degois.publication.issue24
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume22
dspace.entity.typePublication
person.familyNameMatthiesen
person.givenNameRune
person.identifier1319342
person.identifier.ciencia-idBB1A-A606-EE77
person.identifier.orcid0000-0002-6353-2616
person.identifier.scopus-author-id9741897800
rcaap.rightsopenAccess
relation.isAuthorOfPublication67181d3c-b83e-4151-9a74-0ea14aeb7f05
relation.isAuthorOfPublication.latestForDiscovery67181d3c-b83e-4151-9a74-0ea14aeb7f05

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