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Preventing regrettable substitutions

2026-07-10Artigo científico Acesso aberto
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dc.contributor.authorAiello-Holden, Kiara
dc.contributor.authorBartmann, Kristina
dc.contributor.authorBuratti, Franca Maria
dc.contributor.authorCabaton, Nicolas J.
dc.contributor.authorCoppola, Lucia
dc.contributor.authorCorsini, Emanuela
dc.contributor.authorDe la Vieja, Antonio
dc.contributor.authorDirven, Hubert
dc.contributor.authorDusinska, Maria
dc.contributor.authorEl Yamani, Naouale
dc.contributor.authorFranko, Nina
dc.contributor.authorGostner, Johanna M.
dc.contributor.authorGrova, Nathalie
dc.contributor.authorGütter, Louise
dc.contributor.authorIglesias-Hernández, Patricia
dc.contributor.authorIulini, Martina
dc.contributor.authorKodila, Anja
dc.contributor.authorKohl, Yvonne
dc.contributor.authorLori, Gabriele
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMarcon, Francesca
dc.contributor.authorMhaouty-Kodja, Sakina
dc.contributor.authorMposhi, Archibold
dc.contributor.authorNaulé, Lydie
dc.contributor.authorPalleschi, Simonetta
dc.contributor.authorRossi, Barbara
dc.contributor.authorRundén-Pran, Elise
dc.contributor.authorSalani, Francesca
dc.contributor.authorSantori, Nicoletta
dc.contributor.authorSilva, Maria João
dc.contributor.authorDolenc, Marija Sollner
dc.contributor.authorTestai, Emanuela
dc.contributor.authorTorres-Ruiz, Mónica
dc.contributor.authorTurner, Jonathan
dc.contributor.authorViguié, Catherine
dc.contributor.authorZalko, Daniel
dc.contributor.authorTait, Sabrina
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2026-09-07T16:44:01Z
dc.date.available2026-09-07T16:44:01Z
dc.date.issued2026-07-10
dc.descriptionPublisher Copyright: Copyright © 2026 Aiello-Holden, Bartmann, Buratti, Cabaton, Coppola, Corsini, De la Vieja, Dirven, Dusinska, El Yamani, Franko, Gostner, Grova, Gütter, Iglesias-Hernández, Iulini, Kodila, Kohl, Lori, Louro, Marcon, Mhaouty-Kodja, Mposhi, Naulé, Palleschi, Rossi, Rundén-Pran, Salani, Santori, Silva, Dolenc, Testai, Torres-Ruiz, Turner, Viguié, Zalko and Tait.
dc.description.abstractBisphenol A (BPA) alternatives are increasingly used in the manufacture of industrial and consumer products, following regulatory restrictions on BPA. However, insufficient safety data on these substitutes raise concern as regards potential regrettable substitutions. Under the EU Partnership for the Assessment of Risks from Chemicals (PARC), Work Package 5 (WP5) addresses this challenge by applying a human-relevant tiered hazard assessment strategy grounded on OECD test guidelines as first tier and expanding the battery to include NAMs (New Approach Methodologies). Eight BPA alternatives were prioritized for studies addressing key toxicological endpoints, namely, endocrine disruption (ED), developmental neurotoxicity (DNT), immunotoxicity, genotoxicity and carcinogenicity and metabolic fate examination (detoxification vs. potential bioactivation), to enable early identification of biological activity and support cross-endpoint prioritization. This manuscript describes the structure and implementation of the testing framework. This integrated testing strategy proposes a structured approach to identify substances of potential concern, guide targeted higher-tier studies, and support regulatory prioritization. PARC WP5 framework is testing whether coordinated NAM-based methods may contribute to next-generation risk assessment and help prevent regrettable substitutions among BPA alternatives for rapid regulatory adoption. Detailed experimental results will be reported separately upon completion of the project.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2442293
dc.identifier.doi10.3389/ftox.2026.1815869
dc.identifier.issn2673-3080
dc.identifier.otherPURE: 171660731
dc.identifier.otherPURE UUID: 85de8f19-8690-454f-b396-889fc45bf361
dc.identifier.otherScopus: 105046505735
dc.identifier.urihttp://hdl.handle.net/10362/206148
dc.identifier.urlhttps://www.scopus.com/pages/publications/105046505735
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbisphenol a alternatives
dc.subjectcarcinogenicity
dc.subjectdevelopmental neurotoxicity (DNT)
dc.subjectendocrine disruption (ED)
dc.subjecthuman hazard assessment
dc.subjectimmunotoxicity
dc.subjectmetabolism
dc.subjectnew approach methodologies (NAMs)
dc.subjectToxicology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.titlePreventing regrettable substitutionsen
dc.title.subtitlea proposal for a tiered testing approach for BPA alternatives under the PARC initiativeen
dc.typejournal article
degois.publication.titleFrontiers in Toxicology
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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