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The Impact of the Virulence of Pseudomonas aeruginosa Isolated from Dogs

2023-05-11Artigo científico Acesso aberto
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dc.contributor.authorde Sousa, Telma
dc.contributor.authorGarcês, Andreia
dc.contributor.authorSilva, Augusto
dc.contributor.authorLopes, Ricardo
dc.contributor.authorAlegria, Nuno
dc.contributor.authorHébraud, Michel
dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorPoeta, Patricia
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-09-28T22:21:27Z
dc.date.available2023-09-28T22:21:27Z
dc.date.issued2023-05-11
dc.descriptionFunding Information: This research was funded by FCT (Fundação para a Ciência e a Tecnologia) related to PhD grant, through the reference DFA/BD/5332/2020. Publisher Copyright: © 2023 by the authors.
dc.description.abstractPseudomonas aeruginosa is a pathogenic bacterium that can cause serious infections in both humans and animals, including dogs. Treatment of this bacterium is challenging because some strains have developed multi-drug resistance. This study aimed to evaluate the antimicrobial resistance patterns and biofilm production of clinical isolates of P. aeruginosa obtained from dogs. The study found that resistance to various β-lactam antimicrobials was widespread, with cefovecin and ceftiofur showing resistance in 74% and 59% of the isolates tested, respectively. Among the aminoglycosides, all strains showed susceptibility to amikacin and tobramycin, while gentamicin resistance was observed in 7% of the tested isolates. Furthermore, all isolates carried the oprD gene, which is essential in governing the entry of antibiotics into bacterial cells. The study also investigated the presence of virulence genes and found that all isolates carried exoS, exoA, exoT, exoY, aprA, algD, and plcH genes. This study compared P. aeruginosa resistance patterns worldwide, emphasizing regional understanding and responsible antibiotic use to prevent multi-drug resistance from emerging. In general, the results of this study emphasize the importance of the continued monitoring of antimicrobial resistance in veterinary medicine.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent859333
dc.identifier.doi10.3390/vetsci10050343
dc.identifier.issn2306-7381
dc.identifier.otherPURE: 72685108
dc.identifier.otherPURE UUID: 9f0b7b45-2986-4e46-84a8-50e4cf3ca85e
dc.identifier.otherScopus: 85160215463
dc.identifier.otherWOS: 000997527000001
dc.identifier.otherPubMed: 37235426
dc.identifier.otherPubMedCentral: PMC10224390
dc.identifier.urihttp://hdl.handle.net/10362/158439
dc.identifier.urlhttps://www.scopus.com/pages/publications/85160215463
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.subjectantibiotic resistance
dc.subjectdogs
dc.subjectPseudomonas aeruginosa
dc.subjectGeneral Veterinary
dc.titleThe Impact of the Virulence of Pseudomonas aeruginosa Isolated from Dogsen
dc.typejournal article
degois.publication.issue5
degois.publication.titleVeterinary Sciences
degois.publication.volume10
dspace.entity.typePublication
oaire.awardNumberUIDB/00772/2020
oaire.awardNumberLA/P/0059/2020
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication6a51ebc0-c324-4411-91e8-3c0895d77865
relation.isProjectOfPublication4def527f-036a-43ca-8074-de80556bdf24
relation.isProjectOfPublication.latestForDiscovery4def527f-036a-43ca-8074-de80556bdf24

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