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Spinal Radiographic Progression in Early Axial Spondyloarthritis

2019-12Artigo científico Acesso aberto
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dc.contributor.authorRamiro, Sofia
dc.contributor.authorRamiro, Sofia
dc.contributor.authorvan der Heijde, Désirée
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorvan Lunteren, Miranda
dc.contributor.authorMoltó, Anna
dc.contributor.authorFeydy, Antoine
dc.contributor.authord'Agostino, Maria Antonietta
dc.contributor.authorLoeuille, Damien
dc.contributor.authorDougados, Maxime
dc.contributor.authorReijnierse, Monique
dc.contributor.authorClaudepierre, Pascal
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblWiley-Blackwell
dc.date.accessioned2023-01-12T22:11:58Z
dc.date.available2023-01-12T22:11:58Z
dc.date.issued2019-12
dc.description.abstractObjective: To analyze the progression of spinal radiographic damage in patients with early axial spondyloarthritis (SpA). Methods: Axial SpA patients from the DESIR (Devenir des Spondylarthropathies Indifférenciées Récentes) cohort with 5-year spinal (cervical and lumbar) radiographs available (n = 549) were included. Two- and 5-year modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) progression and development of new syndesmophytes (net change: the number of patients with positive change minus the number of patients with negative change divided by the total number of patients) were assessed in subgroups defined at baseline according to the Assessment of SpondyloArthritis international Society axial SpA criteria and its arms, modified New York criteria (mNYC) and the presence of syndesmophytes. Results: Mean ± SD mSASSS progression was 0.2 ± 0.9 at 2 years and 0.4 ± 1.8 at 5 years. Five-year progression was higher in the imaging arm (mean ± SD 0.6 ± 2.3), magnetic resonance imaging (MRI)+/mNYC+ (mean ± SD 1.3 ± 4.0), than in the clinical arm only (mean ± SD 0.1 ± 0.7), and highest in patients with syndesmophytes (mean ± SD 2.7 ± 5.0). At 5 years, 7% of all patients had a net change of any new syndesmophyte; this value was 10% for the imaging arm (mNYC+/MRI+ with 18%), 17% for mNYC+ patients, and 42% for patients with syndesmophytes. Conclusion: Spinal radiographic progression, although limited in early axial SpA, can be captured after 2 years. Inflammation and damage in the sacroiliac joint are associated with higher radiographic progression. The presence of baseline syndesmophytes already strongly predicts the development of further structural damage early in the disease.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent355331
dc.identifier.doi10.1002/acr.23796
dc.identifier.issn2151-464X
dc.identifier.otherPURE: 15687879
dc.identifier.otherPURE UUID: 2f69c098-8107-447a-a100-c6db4596ed05
dc.identifier.otherScopus: 85065910751
dc.identifier.otherPubMed: 30354022
dc.identifier.otherWOS: 000499616600018
dc.identifier.urihttp://hdl.handle.net/10362/147413
dc.identifier.urlhttps://www.scopus.com/pages/publications/85065910751
dc.language.isoeng
dc.peerreviewedyes
dc.subjectRheumatology
dc.titleSpinal Radiographic Progression in Early Axial Spondyloarthritisen
dc.title.subtitleFive-Year Results From the DESIR Cohorten
dc.typejournal article
degois.publication.firstPage1531
degois.publication.issue12
degois.publication.lastPage1707
degois.publication.titleArthritis Care and Research
degois.publication.volume71
dspace.entity.typePublication
person.familyNameRamiro
person.familyNameSepriano
person.givenNameSofia
person.givenNameAlexandre
person.identifier397398
person.identifier.ciencia-idC513-D4F1-EEC3
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.orcid0000-0002-8899-9087
person.identifier.orcid0000-0003-1954-0229
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublication9853406a-2641-440d-a8b1-a516bdb6f32f
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication.latestForDiscovery9853406a-2641-440d-a8b1-a516bdb6f32f

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