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Supercritical CO2 assisted impregnation of ibuprofen on medium-chain-length polyhydroxyalkanoates (mcl-PHA)

2021-08-06Artigo científico Acesso aberto
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dc.contributor.authorMeneses, Liane
dc.contributor.authorCraveiro, Rita
dc.contributor.authorJesus, Ana Rita
dc.contributor.authorReis, Maria A. M.
dc.contributor.authorFreitas, Filomena
dc.contributor.authorPaiva, Alexandre
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-12-20T23:17:33Z
dc.date.available2021-12-20T23:17:33Z
dc.date.issued2021-08-06
dc.descriptionLA/P/0140/2020
dc.description.abstractIn this work, we propose the utilization of scCO2 to impregnate ibuprofen into the mcl- PHA matrix produced by Pseudomonas chlororaphis subs. aurantiaca (DSM 19603). The biopolymer has adhesive properties, is biocompatible and has a melting temperature of 45 °C. Several conditions, namely, pressure (15 and 20 MPa) and impregnation time (30 min, 1 h and 3 h) were tested. The highest ibuprofen content (90.8 ± 6.5 mg of ibuprofen/gPHA) was obtained at 20 MPa and 40 °C, for 1 h, with an impregnation rate of 89 mg/(g.h). The processed mcl-PHA samples suffered a plasticization, as shown by the decrease of 6.5 °C in the Tg, at 20 MPa. The polymer’s crystallinity was also affected concomitantly with the matrices’ ibuprofen content. For all the impregnation conditions tested the release of ibuprofen from the biopolymer followed a type II release profile. This study has demonstrated that the mcl-PHA produced by P. chlororaphis has a great potential for the development of novel topical drug delivery systems.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1835840
dc.identifier.doi10.3390/molecules26164772
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 34359900
dc.identifier.otherPURE UUID: 87eaf446-2dcb-40aa-b9fb-8e88624c27e5
dc.identifier.otherScopus: 85112278465
dc.identifier.otherPubMed: 34443357
dc.identifier.otherPubMedCentral: PMC8400196
dc.identifier.otherWOS: 000690031800001
dc.identifier.otherORCID: /0000-0002-9430-4640/work/105095072
dc.identifier.urihttp://hdl.handle.net/10362/129527
dc.identifier.urlhttps://www.scopus.com/pages/publications/85112278465
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationEnhancing storage stability of vaccines and bacteriophages using Natural Deep Eutectic Solvents
dc.relationDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
dc.relationinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
dc.subjectAlternative technologies
dc.subjectControlled drug release
dc.subjectGreen solvents
dc.subjectIbuprofen
dc.subjectImpregnation
dc.subjectMedium-chain-length polyhydroxyalkanoates
dc.subjectSupercritical carbon dioxide
dc.titleSupercritical CO2 assisted impregnation of ibuprofen on medium-chain-length polyhydroxyalkanoates (mcl-PHA)en
dc.typejournal article
degois.publication.issue16
degois.publication.titleMolecules
degois.publication.volume26
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberSFRH/BD/148510/2019
oaire.awardNumberIF/01146/2015/CP1293/CT0003
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleEnhancing storage stability of vaccines and bacteriophages using Natural Deep Eutectic Solvents
oaire.awardTitleDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F148510%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.fundingStreamInvestigador FCT
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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