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On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction

2023-12-15Recensão Acesso aberto
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dc.contributor.authorConde, Silvia V.
dc.contributor.authorV Conde, Silvia
dc.contributor.authorPolotsky, Vsevolod Y.
dc.contributor.authorJoseph, Vincent
dc.contributor.authorKinkead, Richard
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBlackwell Publishing Ltd
dc.date.accessioned2023-05-04T22:13:17Z
dc.date.available2023-05-04T22:13:17Z
dc.date.issued2023-12-15
dc.descriptionFunding Information: R.K.’s contribution to this text was supported by operating grants from the Canadian Institutes of Health Research. V.P. is supported by the National Institutes of Health grants R01HL133100, R01HL128970, R41HL167326, and R61HL156240. Publisher Copyright: © 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
dc.description.abstractSleep disordered breathing (SDB) is a complex, sex specific and highly heterogeneous group of respiratory disorders. Nevertheless, sleep fragmentation and repeated fluctuations of arterial blood gases for several hours per night are at the core of the problem; together, they impose significant stress to the organism with deleterious consequences on physical and mental health. SDB increases the risk of obesity, diabetes, depression and anxiety disorders; however, the same health issues are risk factors for SDB. So, which came first, the chicken or the egg? What causes the appearance of the first significant apnoeic events during sleep? These are important questions because although moderate to severe SDB affects ∼500 million adults globally, we still have a poor understanding of the origins of the disease, and the main treatments (and animal models) focus on the symptoms rather than the cause. Because obesity, metabolic dysfunction and stress-related neurological disorders generally appear progressively, we discuss how the development of these diseases can lead to specific anatomical and non-anatomical traits of SDB in males and females while considering the impacts of sex steroids. In light of the growing evidence indicating that the carotid bodies are important sensors of key metabolic and endocrine signals associated with stress and dysmetabolism, we propose that these organs play a key role in the process. (Figure presented.).en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1845389
dc.identifier.doi10.1113/JP284113
dc.identifier.issn0022-3751
dc.identifier.otherPURE: 59750000
dc.identifier.otherPURE UUID: 9b8e070c-f66f-480c-9c59-4f51c794ed32
dc.identifier.otherScopus: 85153213864
dc.identifier.otherPubMed: 36988138
dc.identifier.urihttp://hdl.handle.net/10362/152438
dc.identifier.urlhttps://www.scopus.com/pages/publications/85153213864
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcontrol of breathing
dc.subjectdiabetes
dc.subjecthypoxia
dc.subjectleptin
dc.subjectobesity
dc.subjectsexual dimorphism
dc.subjectstress
dc.subjectPhysiology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleOn the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunctionen
dc.title.subtitlewhich came first, the chicken or the egg?en
dc.typereview
degois.publication.firstPage5509
degois.publication.issue24
degois.publication.lastPage5525
degois.publication.titleJournal of Physiology
degois.publication.volume601
dspace.entity.typePublication
person.familyNameVilares Conde
person.givenNameSilvia
person.identifier154176
person.identifier.ciencia-id561E-CF29-600A
person.identifier.orcid0000-0002-5920-5700
person.identifier.scopus-author-id7004283202
rcaap.rightsopenAccess
relation.isAuthorOfPublication898e99d8-61a5-44bc-878a-5e1ac44ca37c
relation.isAuthorOfPublication.latestForDiscovery898e99d8-61a5-44bc-878a-5e1ac44ca37c

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