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Doença intersticial pulmonar grave e mania induzida por corticosteróides em doente com lúpus eritematoso sistémico e síndrome de Sjögren secundária

2017-03-01Artigo científico Acesso aberto
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dc.contributor.authorSilvério Serra, Sofia
dc.contributor.authorSilvério Serra, Sofia
dc.contributor.authorPedrosa, Teresa
dc.contributor.authorFalcão, Sandra
dc.contributor.authorBranco, Jaime
dc.contributor.authorBranco, Jaime
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblBiblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM
dc.date.accessioned2017-09-26T13:49:42Z
dc.date.available2017-09-26T13:49:42Z
dc.date.issued2017-03-01
dc.description.abstractInterstitial lung disease occurs in up to 25% of patients with Sjögren’s syndrome and 2% -8 % of patients with systemic lupus erythematosus. Corticosteroid therapy remains the main treatment for systemic lupus erythematosus. However, it can be associated with several neuropsychiatric disorders especially with prednisolone at a dose of more than 40 mg/day. We present the case of a 51-year-old patient with systemic lupus erythematosus and secondary Sjögren’s syndrome with severe pulmonary involvement four years after the diagnosis. Chest computed tomography revealed neofibrosis and ground glass appearance pattern. After increasing the dose of prednisolone to 60 mg/day, the patient presented a manic episode. There was need of hospitalization and the situation was considered to be secondary to corticosteroids at high doses. Central neurological involvement by organic disease was excluded. We introduced monthly perfusion of cyclophosphamide for six months and later started mycophenolate mofetil 2 g/day, reducing prednisolone to 10 mg/day and maintaining hydroxychloroquine 400 mg/day, with control of disease activity.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5
dc.format.extent673135
dc.identifier.doi10.20344/amp.7297
dc.identifier.issn0870-399X
dc.identifier.otherPURE: 3159110
dc.identifier.otherPURE UUID: 9457760b-a837-41d5-907d-73723e40415e
dc.identifier.otherScopus: 85016717220
dc.identifier.otherPubMed: 28550835
dc.identifier.otherWOS: 000403865300013
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85016717220&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85016717220
dc.language.isopor
dc.peerreviewedyes
dc.subjectAdrenal cortex hormones/adverse effects
dc.subjectInterstitial
dc.subjectLung diseases
dc.subjectLupus erythematosus
dc.subjectMental disorders/ chemically induced
dc.subjectSjögren’s syndrome
dc.subjectSystemic
dc.subjectGeneral Medicine
dc.titleDoença intersticial pulmonar grave e mania induzida por corticosteróides em doente com lúpus eritematoso sistémico e síndrome de Sjögren secundáriapt
dc.title.alternativeSevere interstitial lung disease and manic symptoms secondary to corticosteroids in a patient with systemic lupus erythematosus and secondary Sjögren’s syndromeen
dc.typejournal article
degois.publication.firstPage246
degois.publication.issue3
degois.publication.lastPage250
degois.publication.titleActa Médica Portuguesa
degois.publication.volume30
dspace.entity.typePublication
person.familyNameSilvério Serra
person.familyNameBranco
person.givenNameSofia Margarida
person.givenNameJaime
person.identifier.ciencia-idFE1A-9376-3870
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.orcid0000-0002-8953-4126
person.identifier.orcid0000-0001-7024-4375
person.identifier.scopus-author-id57209881696
person.identifier.scopus-author-id8417815400
rcaap.rightsopenAccess
relation.isAuthorOfPublicationc46b4422-88e8-4b57-9d9e-fbc746e2cb36
relation.isAuthorOfPublication4caea9f3-40dd-4c95-98ec-0120509287c0
relation.isAuthorOfPublication.latestForDiscovery4caea9f3-40dd-4c95-98ec-0120509287c0

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