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Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor

2003-06Artigo científico Acesso aberto
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dc.contributor.authorBetsou, Fotini
dc.contributor.authorBorrego, Maria José
dc.contributor.authorGuillaume, Nicolas
dc.contributor.authorCatry, Maria Anjos
dc.contributor.authorRomão, Sandra
dc.contributor.authorMachado-Caetano, J. A.
dc.contributor.authorSueur, Jean Marie
dc.contributor.authorMention, Jacques
dc.contributor.authorFaille, Nicole
dc.contributor.authorOrfila, Jeanne
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblAmerican Society for Microbiology
dc.date.accessioned2017-09-25T22:04:06Z
dc.date.available2017-09-25T22:04:06Z
dc.date.issued2003-06
dc.description.abstractChlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5
dc.format.extent74850
dc.identifier.doi10.1128/CDLI.10.3.446-450.2003
dc.identifier.issn1071-412X
dc.identifier.otherPURE: 3151616
dc.identifier.otherPURE UUID: f396f019-a33e-4493-9f68-7278c067efa6
dc.identifier.otherScopus: 12444269960
dc.identifier.otherPubMed: 12738647
dc.identifier.otherWOS: 000183022900021
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=12444269960&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/12444269960
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMONOCLONAL-ANTIBODIES
dc.subjectHUMAN CHAPERONIN-10
dc.subjectIDENTIFICATION
dc.subjectAUTOIMMUNITY
dc.subjectPURIFICATION
dc.subjectALLELES
dc.subjectCLONING
dc.subjectMICE
dc.subjectMicrobiology (medical)
dc.subjectImmunology and Allergy
dc.subjectClinical Biochemistry
dc.subjectImmunology
dc.titleCross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factoren
dc.typejournal article
degois.publication.firstPage446
degois.publication.issue3
degois.publication.lastPage450
degois.publication.titleClinical and Diagnostic Laboratory Immunology
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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