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Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population

2023Artigo científico Acesso aberto
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dc.contributor.authorMagalhães, Filipe
dc.contributor.authorAndrade, Claúdia
dc.contributor.authorSimões, Beatriz
dc.contributor.authorBrigham, Fredi
dc.contributor.authorValente, Ruben
dc.contributor.authorMartinez, Pedro
dc.contributor.authorRino, José
dc.contributor.authorSugni, Michela
dc.contributor.authorCoelho, Ana Varela
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblSpringer Verlag
dc.date.accessioned2023-09-30T22:19:02Z
dc.date.available2023-09-30T22:19:02Z
dc.date.issued2023
dc.descriptionPublisher Copyright: © 2023, The Author(s).
dc.description.abstractThe potential to regenerate a damaged body part is expressed to a different extent in animals. Echinoderms, in particular starfish, are known for their outstanding regenerating potential. Differently, humans have restricted abilities to restore organ systems being dependent on limited sources of stem cells. In particular, the potential to regenerate the central nervous system is extremely limited, explaining the lack of natural mechanisms that could overcome the development of neurodegenerative diseases and the occurrence of trauma. Therefore, understanding the molecular and cellular mechanisms of regeneration in starfish could help the development of new therapeutic approaches in humans. In this study, we tackle the problem of starfish central nervous system regeneration by examining the external and internal anatomical and behavioral traits, the dynamics of coelomocyte populations, and neuronal tissue architecture after radial nerve cord (RNC) partial ablation. We noticed that the removal of part of RNC generated several anatomic anomalies and induced behavioral modifications (injured arm could not be used anymore to lead the starfish movement). Those alterations seem to be related to defense mechanisms and protection of the wound. In particular, histology showed that tissue patterns during regeneration resemble those described in holothurians and in starfish arm tip regeneration. Flow cytometry coupled with imaging flow cytometry unveiled a new coelomocyte population during the late phase of the regeneration process. Morphotypes of these and previously characterized coelomocyte populations were described based on IFC data. Further studies of this new coelomocyte population might provide insights on their involvement in radial nerve cord regeneration.en
dc.description.versionpublishersversion
dc.description.versioninpress
dc.format.extent3230409
dc.identifier.doi10.1007/s00441-023-03818-x
dc.identifier.issn0302-766X
dc.identifier.otherPURE: 72374643
dc.identifier.otherPURE UUID: dd346530-82ed-4b39-99fa-f17cfb47dd16
dc.identifier.otherScopus: 85168621702
dc.identifier.otherPubMed: 37606764
dc.identifier.urihttp://hdl.handle.net/10362/158528
dc.identifier.urlhttps://www.scopus.com/pages/publications/85168621702
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCoelomocytes
dc.subjectEchinoderm
dc.subjectFlow cytometry/imaging flow cytometry
dc.subjectMarthasterias glacialis
dc.subjectNerve regeneration
dc.subjectPathology and Forensic Medicine
dc.subjectHistology
dc.subjectCell Biology
dc.titleRegeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte populationen
dc.typejournal article
degois.publication.titleCell and Tissue Research
dspace.entity.typePublication
rcaap.rightsopenAccess

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