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A harmonized occupational biomonitoring approach

2024-09Artigo científico Acesso aberto
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dc.contributor.authorHopf, Nancy B.
dc.contributor.authorRousselle, Christophe
dc.contributor.authorPoddalgoda, Devika
dc.contributor.authorLamkarkach, Farida
dc.contributor.authorBessems, Jos
dc.contributor.authorSchmid, Kaspar
dc.contributor.authorJones, Kate
dc.contributor.authorTakaki, Koki
dc.contributor.authorCasteleyn, Ludwine
dc.contributor.authorZare Jeddi, Maryam
dc.contributor.authorBader, Michael
dc.contributor.authorKoller, Michael
dc.contributor.authorBrowne, Patience
dc.contributor.authorFitzGerald, Rex
dc.contributor.authorViegas, Susana
dc.contributor.authorGöen, Thomas
dc.contributor.authorSantonen, Tiina
dc.contributor.authorVäänänen, Virpi
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorPasanen-Kase, Robert
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblElsevier
dc.date.accessioned2024-09-30T22:34:19Z
dc.date.available2024-09-30T22:34:19Z
dc.date.issued2024-09
dc.descriptionPublisher Copyright: © 2024
dc.description.abstractBiomonitoring has been widely used in assessing exposures in both occupational and public health complementing chemical risk assessments because it measures the concentrations of chemical substances in human body fluids (e.g., urine and blood). Biomonitoring considers all routes and sources of exposure. An occupational biomonitoring guidance document has been elaborated (OECD Occupational Biomonitoring Guidance) within the OECD framework and specifically, the Working Parties on Exposure and Hazard Assessment by scientific experts from 40 institutes and organizations representing 15 countries. The guidance provides practical information for assessing chemical exposures in occupational settings including the three common routes of exposure: inhalation, skin absorption and ingestion due to hand to mouth contact. The elaborated stepwise approach for conducting biomonitoring is tailored for occupational health professionals, scientists, risk assessors, and regulators. It includes methods for selecting appropriate biomarkers, devising sampling strategies, and assessing laboratories for validated analytical methods for the biomarker of interest, and ensuring timely feedback of results. Furthermore, it describes procedures for setting up efficient biomonitoring programs based on the Similar Exposure Group (SEG) approaches. Derived health-based human exposure biomarker assessment values called Occupational Biomonitoring Levels (OBLs) are proposed for use in occupational exposure and risk assessment. It also helps with the interpretation of biomonitoring results routinely collected and procedures for communicating biomonitoring results at individual, collective, and workplace levels. Ethical considerations associated with biomonitoring are also discussed. The ultimate goal of this biomonitoring approach is to promote harmonized application and interpretation of biomarkers as well as evidence-based occupational risk management measures.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1909636
dc.identifier.doi10.1016/j.envint.2024.108990
dc.identifier.issn0160-4120
dc.identifier.otherPURE: 100298695
dc.identifier.otherPURE UUID: 4697b1c1-1264-413a-b865-32102180679d
dc.identifier.otherScopus: 85203296490
dc.identifier.otherPubMed: 39244955
dc.identifier.otherWOS: 001317259700001
dc.identifier.urihttp://hdl.handle.net/10362/172762
dc.identifier.urlhttps://www.scopus.com/pages/publications/85203296490
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiological monitoring
dc.subjectEffect biomarkers
dc.subjectExposure biomarkers
dc.subjectRisk assessment
dc.subjectRisk management
dc.subjectToxicokinetics
dc.subjectGeneral Environmental Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleA harmonized occupational biomonitoring approachen
dc.typejournal article
degois.publication.titleEnvironment International
degois.publication.volume191
dspace.entity.typePublication
rcaap.rightsopenAccess

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