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Higher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patients

2017-07-01Artigo científico Acesso aberto
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dc.contributor.authorAdragao, Teresa
dc.contributor.authorFerreira, Anibal
dc.contributor.authorFrazao, Joao M.
dc.contributor.authorPapoila, Ana Luisa
dc.contributor.authorPapoila, A.L.
dc.contributor.authorPinto, Iola
dc.contributor.authorMonier-Faugere, Marie Claude
dc.contributor.authorMalluche, Hartmut H.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblPLOS - Public Library of Science
dc.date.accessioned2017-09-29T22:04:06Z
dc.date.available2017-09-29T22:04:06Z
dc.date.issued2017-07-01
dc.description.abstractBackground and objectives In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. Design, setting, participants and measurements In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). Results SVCS3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS3 versus 4% of patients with a SVCS<3, (p<0.001). Conclusion Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent2797099
dc.identifier.doi10.1371/journal.pone.0179868
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 3157026
dc.identifier.otherPURE UUID: 6621fcd8-fce9-4b25-a468-c737cd09ed79
dc.identifier.otherScopus: 85022183209
dc.identifier.otherWOS: 000405464100024
dc.identifier.otherPubMed: 28686736
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85022183209&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85022183209
dc.language.isoeng
dc.peerreviewedyes
dc.subjectSTAGE RENAL-DISEASE
dc.subjectCORONARY-ARTERY CALCIFICATION
dc.subjectCARDIOVASCULAR RISK
dc.subjectCALCIUM
dc.subjectDIALYSIS
dc.subjectOSTEODYSTROPHY
dc.subjectMORTALITY
dc.subjectSTIFFNESS
dc.subjectHISTOMORPHOMETRY
dc.subjectPROGRESSION
dc.subjectGeneral Medicine
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectGeneral Agricultural and Biological Sciences
dc.titleHigher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patientsen
dc.typejournal article
degois.publication.firstPage
degois.publication.issue7
degois.publication.lastPage
degois.publication.titlePLoS ONE
degois.publication.volume12
dspace.entity.typePublication
person.familyNamePapoila
person.givenNameAna Luisa
person.identifier.ciencia-id251C-0273-1068
person.identifier.orcid0000-0002-2918-8364
person.identifier.ridS-2515-2016
person.identifier.scopus-author-id6507532321
rcaap.rightsopenAccess
relation.isAuthorOfPublication5ce1bd05-e7a4-4bd0-9527-f511c0889095
relation.isAuthorOfPublication.latestForDiscovery5ce1bd05-e7a4-4bd0-9527-f511c0889095

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