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Advances in green catalysis for the synthesis of medicinally relevant N-heterocycles

2021-09-15Recensão Acesso aberto
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dc.contributor.authorSantos, Ana Sofia
dc.contributor.authorRaydan, Daniel
dc.contributor.authorCunha, José C.
dc.contributor.authorViduedo, Nuno
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorMarques, M. Manuel B.
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-08-01T22:25:55Z
dc.date.available2022-08-01T22:25:55Z
dc.date.issued2021-09-15
dc.descriptionPD/BD/05960/2020
dc.description.abstractN-heterocycles, both saturated and unsaturated, are ubiquitous biologically active molecules that are extremely appealing scaffolds in drug discovery programs. Although classical synthetic methods have been developed to access many relevant N-heterocyclic scaffolds, representing well-established and reliable routes, some do not meet the needs of sustainability. In this context, several advances have been made towards the sustainable synthesis of N-heterocycles. This review focuses on the most recent examples from the last five years of catalytic synthesis of several heterocyclic compounds of medicinal relevance. Thus, the synthesis of isoindoloquinazolines, quinazolines and azaindoles, among others, are covered. The synthetic methods selected include the use of homo-geneous and heterogeneous catalysts and the use of alternative and sustainable methods such as, for example, metal-catalyzed acceptorless coupling and one-pot reactions. The green aspects of the individual synthetic approaches are highlighted, and the scope of each methodology is described.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4014534
dc.identifier.doi10.3390/catal11091108
dc.identifier.issn2073-4344
dc.identifier.otherPURE: 45749703
dc.identifier.otherPURE UUID: a4e152a5-46c4-493c-a64b-8191f293f80c
dc.identifier.otherScopus: 85114916214
dc.identifier.otherWOS: 000699274400001
dc.identifier.urihttp://hdl.handle.net/10362/142770
dc.identifier.urlhttps://www.scopus.com/pages/publications/85114916214
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAdvancing structural diversity on heterocycles via sustainable approaches: novel metal-catalyzed routes towards azaindoles
dc.relation1Pot2Cat: One-pot bimetallic catalyzed synthesis of challenging N-heterocycles
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QOR%2F0712%2F2020/PT
dc.subjectBioactive compounds
dc.subjectGreen catalysis
dc.subjectMetal-catalysis
dc.subjectN-heterocycles
dc.subjectSynthesis
dc.subjectCatalysis
dc.subjectPhysical and Theoretical Chemistry
dc.titleAdvances in green catalysis for the synthesis of medicinally relevant N-heterocyclesen
dc.typereview
degois.publication.issue9
degois.publication.titleCatalysts
degois.publication.volume11
dspace.entity.typePublication
oaire.awardNumberUIDP/50006/2020
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberPD/BD/142876/2018
oaire.awardNumberPTDC/QUI-QOR/0712/2020
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAdvancing structural diversity on heterocycles via sustainable approaches: novel metal-catalyzed routes towards azaindoles
oaire.awardTitle1Pot2Cat: One-pot bimetallic catalyzed synthesis of challenging N-heterocycles
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F142876%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QOR%2F0712%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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