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Biomimetic Ghost Nanomedicine-Based Optotheranostics for Cancer

2024-07-10Recensão Acesso aberto
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dc.contributor.authorPrasad, Rajendra
dc.contributor.authorJyothi, Vaskuri G.S.
dc.contributor.authorKommineni, Nagavendra
dc.contributor.authorBulusu, Ravi Teja
dc.contributor.authorMendes, Bárbara B.
dc.contributor.authorLovell, Jonathan F.
dc.contributor.authorConde, João
dc.contributor.authorConde, João
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblACS - American Chemical Society
dc.date.accessioned2024-06-18T01:36:55Z
dc.date.available2024-06-18T01:36:55Z
dc.date.issued2024-07-10
dc.descriptionPublisher Copyright: © 2024 The Authors. Published by American Chemical Society.
dc.description.abstractTheranostic medicine combines diagnostics and therapeutics, focusing on solid tumors at minimal doses. Optically activated photosensitizers are significant examples owing to their photophysical and chemical properties. Several optotheranostics have been tested that convert light to imaging signals, therapeutic radicals, and heat. Upon light exposure, conjugated photosensitizers kill tumor cells by producing reactive oxygen species and heat or by releasing cancer antigens. Despite clinical trials, these molecularly conjugated photosensitizers require protection from their surroundings and a localized direction for site-specific delivery during blood circulation. Therefore, cell membrane biomimetic ghosts have been proposed for precise and safe delivery of these optically active large molecules, which are clinically relevant because of their biocompatibility, long circulation time, bypass of immune cell recognition, and targeting ability. This review focuses on the role of biomimetic nanoparticles in the treatment and diagnosis of tumors through light-mediated diagnostics and therapy, providing insights into their preclinical and clinical status.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent10409051
dc.identifier.doi10.1021/acs.nanolett.4c01534
dc.identifier.issn1530-6984
dc.identifier.otherPURE: 93415246
dc.identifier.otherPURE UUID: d33c9a62-afd5-4b8f-b890-bbb091bc8e22
dc.identifier.otherScopus: 85195564853
dc.identifier.otherPubMed: 38848540
dc.identifier.urihttp://hdl.handle.net/10362/168708
dc.identifier.urlhttps://www.scopus.com/pages/publications/85195564853
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiomimetics
dc.subjectCell Ghosts
dc.subjectOptotheranostics
dc.subjectPhototherapeutics
dc.subjectSolid tumors
dc.subjectBioengineering
dc.subjectGeneral Chemistry
dc.subjectGeneral Materials Science
dc.subjectCondensed Matter Physics
dc.subjectMechanical Engineering
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBiomimetic Ghost Nanomedicine-Based Optotheranostics for Canceren
dc.typereview
degois.publication.firstPage8217
degois.publication.issue27
degois.publication.lastPage8231
degois.publication.titleNano Letters
degois.publication.volume24
dspace.entity.typePublication
person.familyNameConde
person.givenNameJoão
person.identifier807432
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.orcid0000-0001-8422-6792
person.identifier.ridF-2231-2011
person.identifier.scopus-author-id56992468300
rcaap.rightsopenAccess
relation.isAuthorOfPublication33ca4178-1b25-4b5e-ae16-b2500abe4c58
relation.isAuthorOfPublication.latestForDiscovery33ca4178-1b25-4b5e-ae16-b2500abe4c58

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NMS: ToxOmics - Artigos em revista internacional com arbitragem científica