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Antibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coating

2023-07-13Artigo científico Acesso aberto
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dc.contributor.authorHammami, Imen
dc.contributor.authorGavinho, Sílvia Rodrigues
dc.contributor.authorJakka, Suresh Kumar
dc.contributor.authorValente, Manuel Almeida
dc.contributor.authorGraça, Manuel Pedro Fernandes
dc.contributor.authorPádua, Ana Sofia
dc.contributor.authorSilva, Jorge Carvalho
dc.contributor.authorSá-Nogueira, Isabel
dc.contributor.authorBorges, João Paulo
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-11-07T22:09:10Z
dc.date.available2023-11-07T22:09:10Z
dc.date.issued2023-07-13
dc.descriptionThis research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology—for the UI/DB/151287/2021). S.K.J. acknowledges FCT—Fundaçao para a Ciência e Tecnologia, Portugal, I.P.—in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors.
dc.description.abstractBiofilm-related implant infections pose a substantial threat to patients, leading to inflammation in the surrounding tissue, and often resulting in implant loss and the necessity for additional surgeries. Overcoming this implantology challenge is crucial to ensure the success and durability of implants. This study shows the development of antibacterial materials for implant coatings by incorporating copper into 45S5 Bioglass®. By combining the regenerative properties of Bioglass® with the antimicrobial effects of copper, this material has the potential to prevent infections, enhance osseointegration and improve the long-term success of implants. Bioglasses modified with various concentrations of CuO (from 0 to 8 mol%) were prepared with the melt-quenching technique. Structural analysis using Raman and FTIR spectroscopies did not reveal significant alterations in the bioglasses structure with the addition of Cu. The antibacterial activity of the samples was assessed against Gram-positive and Gram-negative bacteria, and the results demonstrated significant inhibition of bacterial growth for the bioglass with 0.5 mol% of CuO. Cell viability studies indicated that the samples modified with up to 4 mol% of CuO maintained good cytocompatibility with the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the bioactivity assessment demonstrated the formation of a calcium phosphate (CaP)-rich layer on the surfaces of all bioglasses within 24 h. Our findings show that the inclusion of copper in the bioglass offers a significant enhancement in its potential as a coating material for implants, resulting in notable advancements in both antibacterial efficacy and osteointegration properties.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17
dc.format.extent6619899
dc.identifier.doi10.3390/jfb14070369
dc.identifier.issn2079-4983
dc.identifier.otherPURE: 75588461
dc.identifier.otherPURE UUID: 2f72f5c3-bf1c-41c5-8022-abbd231cac60
dc.identifier.otherScopus: 85170110513
dc.identifier.otherWOS: 001039543100001
dc.identifier.otherPubMed: 37504864
dc.identifier.otherPubMedCentral: PMC10381177
dc.identifier.otherORCID: /0000-0001-9959-4272/work/151367255
dc.identifier.otherORCID: /0000-0002-3996-6545/work/151413850
dc.identifier.urihttp://hdl.handle.net/10362/159675
dc.identifier.urlhttps://www.scopus.com/pages/publications/85170110513
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationCustomization of implants coated with multifunctional biomaterials
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F148233%2F2019/PT
dc.subjectantibacterial activity
dc.subjectbioactivity
dc.subjectBioglass
dc.subjectcopper
dc.subjectimplant coating
dc.subjectosseointegration
dc.subjectBiomaterials
dc.subjectBiomedical Engineering
dc.titleAntibacterial Biomaterial Based on Bioglass Modified with Copper for Implants Coatingen
dc.typejournal article
degois.publication.issue7
degois.publication.titleJournal of Functional Biomaterials
degois.publication.volume14
dspace.entity.typePublication
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardNumberSFRH/BD/148233/2019
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleCustomization of implants coated with multifunctional biomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F148233%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
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