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MicroRNAs and cancer drug resistance: over two thousand characters in search of a role

2019-09-16Artigo científico Acesso aberto
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dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorRueff, José
dc.contributor.authorRueff, Jose
dc.contributor.authorRodrigues, António Sebastião
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblOAE Publishing
dc.date.accessioned2019-10-04T22:53:44Z
dc.date.available2019-10-04T22:53:44Z
dc.date.issued2019-09-16
dc.description.abstractMicroRNAs (miRNAs), a group of small regulatory noncoding RNAs, transformed our thinking on gene regulation. More than two thousand human miRNAs have been identified thus far. These bind imperfectly to the 3’-untranslated region of target mRNA and have been involved in several pathological conditions including cancer. In fact, major hallmarks of cancer, such as the cell cycle, cell proliferation, survival and invasion are modulated by miRNAs. Cancer drug resistance (CDR) has also been described as being modulated by miRNAs. CDR remains a burden for cancer therapy and patients’ outcome, often resulting in more aggressive tumours that tend to metastasize to distant organs. In this review we discuss the role of miRNAs influencing drug metabolism and drug influx/efflux, two important mechanisms of CDR.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1434592
dc.identifier.doi10.20517/cdr.2019.55
dc.identifier.issn2578-532X
dc.identifier.otherPURE: 14889171
dc.identifier.otherPURE UUID: 4f6e2747-cd16-411d-aca7-ae15381f137a
dc.identifier.othercrossref: 10.20517/cdr.2019.55
dc.identifier.otherScopus: 85083830583
dc.identifier.otherPubMed: 35582590
dc.identifier.otherWOS: 000848699500017
dc.identifier.urihttps://cdrjournal.com/article/view/3216
dc.identifier.urlhttps://cdrjournal.com/article/view/3216
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMicroRNAs
dc.subjectgene regulation
dc.subjectcancer drug resistance
dc.subjectdrug transporters
dc.subjectdrug metabolism
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMicroRNAs and cancer drug resistance: over two thousand characters in search of a roleen
dc.typejournal article
degois.publication.firstPage618
degois.publication.lastPage633
degois.publication.titleCancer Drug Resistance
degois.publication.volume2
dspace.entity.typePublication
person.familyNameRueff
person.givenNameJose
person.identifier793666
person.identifier.ciencia-id0E15-908D-EA21
person.identifier.orcid0000-0002-8456-7295
person.identifier.ridE-6426-2013
person.identifier.scopus-author-id7006536439
rcaap.rightsopenAccess
relation.isAuthorOfPublication91a3b5ac-0328-498d-8cb8-08555b202306
relation.isAuthorOfPublication.latestForDiscovery91a3b5ac-0328-498d-8cb8-08555b202306

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