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Enzymatic Hydrolysis Systems Enhance the Efficiency and Biological Properties of Hydrolysates from Frozen Fish Processing Co-Products

2025-01Artigo científico Acesso aberto
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dc.contributor.authorSapatinha, Maria
dc.contributor.authorCamacho, Carolina
dc.contributor.authorPais-Costa, Antónia Juliana
dc.contributor.authorFernando, Ana Luísa
dc.contributor.authorMarques, António
dc.contributor.authorPires, Carla
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-07-04T21:16:20Z
dc.date.available2025-07-04T21:16:20Z
dc.date.issued2025-01
dc.descriptionThis work was developed within the scope of the “BLUE BIOECONOMY INNO- VATION PACT” (Project No. C644915664-00000026) funded by NextGenerationEU, under the incentive of the “Agenda for Business Innovation” of the recovery and resilience plan (PRR). © 2024 by the authors. Licensee MDPI, Basel, Switzerland
dc.description.abstractCo-products from the frozen fish processing industry often lead to financial losses. Therefore, it is essential to transform these co-products into profitable goods. This study explores the production of fish protein hydrolysates (FPH) from three co-products: the heads and bones of black scabbardfish (Aphanopus carbo), the carcasses of gilthead seabream (Sparus aurata), and the trimmings of Nile perch (Lates niloticus). Four enzymatic hydrolysis systems were tested: an endopeptidase (Alcalase, A), an exopeptidase (Protana, P), two-stage hydrolysis with an endopeptidase followed by an exopeptidase (A + P), and a single stage with endo- and exopeptidase (AP). The results show that combined enzymatic treatments, especially single-stage Alcalase and Protana (AP), achieved high protein yields (80%) and enhanced degrees of hydrolysis (34 to 49%), producing peptides with lower molecular weights. FPH exhibited significant antioxidant activity, in 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, with EC50 values below 5 mg/mL. Additionally, AP hydrolysates demonstrated over 60% angiotensin-converting enzyme (ACE) inhibition at 5 mg/mL, indicating potential antihypertensive applications. Antidiabetic and anti-Alzheimer activities were present, but at relatively low levels. AP hydrolysates, especially from gilthead seabream, proved to be the most promising. This study highlights the value of fish co-products as sources of functional peptides, contributing to waste reduction, and their potential applications in food, agriculture, and nutraceuticals.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1414584
dc.identifier.doi10.3390/md23010014
dc.identifier.issn1660-3397
dc.identifier.otherPURE: 110603056
dc.identifier.otherPURE UUID: 5ae3ea0f-7769-480e-a828-cd825e4ae259
dc.identifier.otherScopus: 85216765998
dc.identifier.otherPubMed: 39852515
dc.identifier.otherWOS: 001404256800001
dc.identifier.otherORCID: /0000-0001-9270-3982/work/187257690
dc.identifier.urihttp://hdl.handle.net/10362/184832
dc.identifier.urlhttps://www.scopus.com/pages/publications/85216765998
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04077%2F2020/PT
dc.relationMechanical Engineering and Resource Sustainability Center
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationinfo:eu-repo/grantAgreement/FCT//2023.02017.BDANA/PT
dc.subjectAlcalase
dc.subjectanti-hypertensive
dc.subjectantioxidant
dc.subjectbioactive compounds
dc.subjectmolecular weight distribution
dc.subjectProtana
dc.subjectsequential hydrolysis
dc.subjectsimultaneous hydrolysis
dc.subjectzero waste
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectSDG 12 - Responsible Consumption and Production
dc.subjectSDG 9 - Industry, Innovation, and Infrastructure
dc.titleEnzymatic Hydrolysis Systems Enhance the Efficiency and Biological Properties of Hydrolysates from Frozen Fish Processing Co-Productsen
dc.typejournal article
degois.publication.issue1
degois.publication.titleMarine Drugs
degois.publication.volume23
dspace.entity.typePublication
oaire.awardNumberUIDB/04077/2020
oaire.awardNumberUIDP/04077/2020
oaire.awardNumberUIDB/04423/2020
oaire.awardNumberUIDP/04423/2020
oaire.awardNumber2023.02017.BDANA
oaire.awardTitleMechanical Engineering and Resource Sustainability Center
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04077%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F04077%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2023.02017.BDANA/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
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