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Algae-Based Supplements Claiming Weight Loss Properties

2024-03-05Artigo científico Acesso aberto
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dc.contributor.authorFernandes, Fátima
dc.contributor.authorMartins, Raquel
dc.contributor.authorBarbosa, Mariana
dc.contributor.authorValentão, Patrícia
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-02-14T21:18:10Z
dc.date.available2025-02-14T21:18:10Z
dc.date.issued2024-03-05
dc.descriptionFunding Information: This work received financial support from Portuguese national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIDP/5006/2020. F. Fernandes thanks FCT for funding through program DL 57/2016—Norma transitória (Ref. DL57/2016/CP1346/CT0018). Publisher Copyright: © 2024 by the authors.
dc.description.abstractThe worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption safety remains inadequately addressed. In this work, commercially available Arthrospira (Spirulina) platensis Gomont and/or Fucus vesiculosus L. supplements showed moderate capacity to inhibit the activity of carbohydrate-metabolizing enzymes, and to scavenge biologically relevant reactive species. IC25 values varying between 4.54 ± 0.81 and 66.73 ± 5.91 µg of dry extract/mL and between 53.74 ± 8.42 and 1737.96 ± 98.26 µg of dry extract/mL were obtained for α-glucosidase and aldose reductase, respectively. A weaker effect towards α-amylase activity was observed, with a maximum activity of the extracts not going beyond 33%, at the highest concentrations tested. Spirulina extracts showed generally better effects than those from F. vesiculosus. Similar results were observed concerning the antiradical capacity. In a general way, the extracts were able to intercept the in vitro-generated reactive species nitric oxide (•NO) and superoxide anion (O2•−) radicals, with better results for O2•−scavenging with the spirulina samples (IC25 values of 67.16 and 122.84 µg of dry extract/mL). Chemically, similar pigment profiles were observed between spirulina supplements and the authenticated counterpart. However, fucoxanthin, the chemotaxonomic marker of brown seaweeds, was not found in F. vesiculosus samples, pointing to the occurrence of a degradation phenomenon before, during, or after raw material processing. Our findings can contribute to providing data to allow regulatory entities (e.g., EFSA and FDA) to better rule these products in a way that can benefit society.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1676655
dc.identifier.doi10.3390/md22030123
dc.identifier.issn1660-3397
dc.identifier.otherPURE: 99744563
dc.identifier.otherPURE UUID: 188a6196-547d-4e51-9835-8267fc53ac6c
dc.identifier.otherScopus: 85188950533
dc.identifier.otherWOS: 001193037200001
dc.identifier.otherPubMed: 38535464
dc.identifier.otherPubMedCentral: PMC10971825
dc.identifier.urihttp://hdl.handle.net/10362/179055
dc.identifier.urlhttps://www.scopus.com/pages/publications/85188950533
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationInnovative approaches for pancreatic cancer: Decoding and manipulating immune response to short sialylated O-glycans
dc.subjectalgae
dc.subjectanti-obesity
dc.subjectantioxidant
dc.subjectfood supplements
dc.subjectFucus vesiculosus
dc.subjectquality control
dc.subjectspirulina
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAlgae-Based Supplements Claiming Weight Loss Propertiesen
dc.title.subtitleAuthenticity Control and Scientific-Based Evidence on Their Effectivenessen
dc.typejournal article
degois.publication.issue3
degois.publication.titleMarine Drugs
degois.publication.volume22
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumber2022.04607.PTDC
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleInnovative approaches for pancreatic cancer: Decoding and manipulating immune response to short sialylated O-glycans
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.04607.PTDC/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication0b65af2f-261a-4565-98a1-8f22ee53e0f6
relation.isProjectOfPublication.latestForDiscoveryadc84c24-ba1d-4bcd-b753-2128ce9a5faa

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