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Absolute Hyperglycemia versus Stress Hyperglycemia Ratio for the Prognosis of Hospitalized Patients with COVID-19 in the First Months of the Pandemic

2023-02Artigo científico Acesso aberto
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dc.contributor.authorMatias, Alexandra A.
dc.contributor.authorManique, Inês
dc.contributor.authorSabino, Teresa
dc.contributor.authorRego, Teresa
dc.contributor.authorMihon, Claudia
dc.contributor.authorPanarra, António
dc.contributor.authorRizzo, Manfredi
dc.contributor.authorSilva-Nunes, José
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSpringer
dc.date.accessioned2023-01-09T22:16:53Z
dc.date.available2023-01-09T22:16:53Z
dc.date.issued2023-02
dc.descriptionPublisher Copyright: © 2022, The Author(s).
dc.description.abstractDiabetes is a risk factor for greater severity of coronavirus disease 2019 (COVID-19). The stress hyperglycemia ratio (SHR) is an independent predictor of critical illness, and it is reported to have a stronger association than absolute hyperglycemia. The aim of this study was to assess the relationship of absolute hyperglycemia and SHR with the severity of COVID-19, since there are no studies investigating SHR in patients with COVID-19. We conducted a retrospective observational study on hospitalized patients with COVID-19 in the first months of the pandemic, regarding absolute hyperglycemia, SHR, and severity outcomes. Of the 374 patients, 28.1% had a previous diagnosis of type 2 diabetes. Absolute hyperglycemia (64.8% versus 22.7%; p < 0.01) and SHR [1.1 (IQR 0.9–1.3) versus 1.0 (IQR 0.9–1.2); p < 0.001] showed a statistically significant association with previous diabetes. Absolute hyperglycemia showed a significant association with clinical severity of COVID-19 (79.0% versus 62.7%; p < 0.001), need for oxygen therapy (74.8% versus 54.4%; p < 0.001), invasive mechanical ventilation (28.6% versus 11.6%; p < 0.001), and intensive care unit (30.3% versus 14.9%; p = 0.002), but not with mortality; by contrast, there was no statistically significant association between SHR and all these parameters. Our results are in agreement with the literature regarding the impact of absolute hyperglycemia on COVID-19 severity outcomes, while SHR was not a significant marker. We therefore suggest that SHR should not be evaluated in all patients admitted in the hospital for COVID-19, and we encourage the standard measures at admission of blood glucose and HbA1c levels.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent308864
dc.identifier.doi10.1007/s13300-022-01347-4
dc.identifier.issn1869-6953
dc.identifier.otherPURE: 49701124
dc.identifier.otherPURE UUID: 2e7352b1-8d50-47b6-9a5d-34baa061e7da
dc.identifier.otherScopus: 85144949035
dc.identifier.otherWOS: 000904864400002
dc.identifier.otherPubMed: 36574200
dc.identifier.urihttp://hdl.handle.net/10362/147245
dc.identifier.urlhttps://www.scopus.com/pages/publications/85144949035
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCOVID-19
dc.subjectDiabetes
dc.subjectHyperglycemia
dc.subjectPrognosis
dc.subjectStress hyperglycemia ratio
dc.subjectInternal Medicine
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAbsolute Hyperglycemia versus Stress Hyperglycemia Ratio for the Prognosis of Hospitalized Patients with COVID-19 in the First Months of the Pandemicen
dc.title.subtitleA Retrospective Studyen
dc.typejournal article
degois.publication.firstPage335
degois.publication.issue2
degois.publication.lastPage346
degois.publication.titleDiabetes Therapy
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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