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HBM4EU occupational biomonitoring study on e-waste

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dc.contributor.authorScheepers, Paul T. J.
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGalea, Karen S.
dc.contributor.authorGodderis, Lode
dc.contributor.authorHardy, Emilie
dc.contributor.authorKnudsen, Lisbeth E.
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMahiout, Selma
dc.contributor.authorNdaw, Sophie
dc.contributor.authorPoels, Katrien
dc.contributor.authorPorras, Simo P.
dc.contributor.authorSilva, Maria J.
dc.contributor.authorTavares, Ana Maria
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorSantonen, Tiina
dc.contributor.authorMartins, Carla
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblMolecular Diversity Preservation International (MDPI)
dc.date.accessioned2021-12-13T23:42:12Z
dc.date.available2021-12-13T23:42:12Z
dc.date.issued2021
dc.description.abstractWorkers involved in the processing of electronic waste (e-waste) are potentially exposed to toxic chemicals. If exposure occurs, this may result in uptake and potential adverse health effects. Thus, exposure surveillance is an important requirement for health risk management and prevention of occupational disease. Human biomonitoring by measurement of specific biomarkers in body fluids is considered as an effective method of exposure surveillance. The aim of this study is to investigate the internal exposure of workers processing e-waste using a human biomonitoring approach, which will stimulate improved work practices and contribute to raising awareness of potential hazards. This exploratory study in occupational exposures in e-waste processing is part of the European Human Biomonitoring Initiative (HBM4EU). Here we present a study protocol using a cross sectional survey design to study worker’s exposures and compare these to the exposure of subjects preferably employed in the same company but with no known exposure to industrial recycling of e-waste. The present study protocol will be applied in six to eight European countries to ensure standardised data collection. The target population size is 300 exposed and 150 controls. Biomarkers of exposure for the following chemicals will be used: chromium, cadmium and lead in blood and urine; brominated flame retardants and polychlorobiphenyls in blood; mercury, organophosphate flame retardants and phthalates in urine, and chromium, cadmium, lead and mercury in hair. In addition, the following effect biomarkers will be studied: micronuclei, epigenetic, oxidative stress, inflammatory markers and telomere length in blood and metabolomics in urine. Occupational hygiene sampling methods (airborne and settled dust, silicon wristbands and handwipes) and contextual information will be collected to facilitate the interpretation of the biomarker results and discuss exposure mitigating.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent652840
dc.identifier.doi10.3390/ijerph182412987
dc.identifier.issn1660-4601
dc.identifier.otherPURE: 35358028
dc.identifier.otherPURE UUID: dafb8747-9609-4130-94d3-46404716142f
dc.identifier.othercrossref: 10.3390/ijerph182412987
dc.identifier.otherScopus: 85120800633
dc.identifier.otherORCID: /0000-0001-7930-2914/work/108682683
dc.identifier.otherWOS: 000739023100001
dc.identifier.otherPubMed: 34948598
dc.identifier.otherPubMedCentral: PMC8701897
dc.identifier.urihttp://hdl.handle.net/10362/129162
dc.identifier.urlhttps://www.mdpi.com/1660-4601/18/24/12987
dc.language.isoeng
dc.peerreviewedyes
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHBM4EU occupational biomonitoring study on e-wasteen
dc.title.subtitlestudy protocolen
dc.typejournal article
degois.publication.issue24
degois.publication.titleInternational Journal of Environmental Research and Public Health
degois.publication.volume18
dspace.entity.typePublication
rcaap.rightsopenAccess

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