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Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)

2022-08-08Artigo científico Acesso aberto
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dc.contributor.authorÁvila-Gálvez, María Ángeles
dc.contributor.authorRafael-Pita, Carlos
dc.contributor.authorFernández, Naiara
dc.contributor.authorBaixinho, João
dc.contributor.authorAnastácio, José D.
dc.contributor.authorCankar, Katarina
dc.contributor.authorBosch, Dirk
dc.contributor.authorNunes dos Santos, Cláudia
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2022-09-08T22:49:53Z
dc.date.available2022-09-08T22:49:53Z
dc.date.issued2022-08-08
dc.descriptionFunding Information: This research has been supported by the EU Horizon 2020 research & innovation programme (H2020-NMBP-BIO-2017, project CHIC grant agreement no. 760891). Publisher Copyright: © 2022 The Royal Society of Chemistry.
dc.description.abstractSARS-CoV-2 is a highly transmissible and pathogenic coronavirus causing a respiratory disease that emerged in 2019, leading to a public health emergency situation which continues to date. The treatment options are still very limited and vaccines available are less effective against new variants. SARS-CoV-2 enzymes, namely main protease (Mpro) and papain-like protease (PLpro), play a pivotal role in the viral life cycle, making them a putative drug target. Here, we described for the first time the potential inhibitory activity of chicory extract against both proteases. Besides, we have identified that the four most abundant sesquiterpene lactones in chicory inhibited these proteases, showing an effective binding in the active sites of Mpro and PLpro. This paper provides new insight for further drug development or food-based strategies for the prevention of SARS-CoV-2 by targeting viral proteases.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2770817
dc.identifier.doi10.1039/d2fo00933a
dc.identifier.issn2042-6496
dc.identifier.otherPURE: 46238766
dc.identifier.otherPURE UUID: 6e66e4ee-b83e-44f4-8979-e8f92f8dd26c
dc.identifier.otherScopus: 85136279773
dc.identifier.otherORCID: /0000-0002-5809-1924/work/118700370
dc.identifier.otherWOS: 000837428100001
dc.identifier.urihttp://hdl.handle.net/10362/143612
dc.identifier.urlhttps://www.scopus.com/pages/publications/85136279773
dc.language.isoeng
dc.peerreviewedyes
dc.subjectFood Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTargeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)en
dc.typejournal article
degois.publication.firstPage8977
degois.publication.issue17
degois.publication.lastPage8988
degois.publication.titleFood and Function
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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