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Metabolomic fingerprinting of salinispora From Atlantic Oceanic Islands

2018-12-11Artigo científico Acesso aberto
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dc.contributor.authorBauermeister, Anelize
dc.contributor.authorVelasco-Alzate, Karen
dc.contributor.authorDias, Tiago
dc.contributor.authorMacedo, Helena
dc.contributor.authorFerreira, Elthon G.
dc.contributor.authorJimenez, Paula C.
dc.contributor.authorLotufo, Tito M.C.
dc.contributor.authorLopes, Norberto P.
dc.contributor.authorGaudêncio, Susana P.
dc.contributor.authorCosta-Lotufo, Letícia V.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.pblFrontiers Research Foundation
dc.date.accessioned2023-10-25T22:15:48Z
dc.date.available2023-10-25T22:15:48Z
dc.date.issued2018-12-11
dc.descriptionThis work was supported by the Unidade de Ciências Biomoleculares Aplicadas-UCIBIO which is financed by co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728. FCT through grants PTDC/QUIQUI/119116/2010. This work was also supported by Brazilian agencies CAPES, CNPq and FAPESP (2017/17648-4; 2015/17177-6).
dc.description.abstractSalinispora (Micromonosporaceae) is an obligate marine bacterium genus consisting of three species that share over 99% 16S rRNA identity. The genome and biosynthetic pathways of the members of this genus have been widely investigated due to their production of species-specific metabolites. However, despite the species' high genetic similarity, site-specific secondary metabolic gene clusters have been found in Salinispora strains collected at different locations. Therefore, exploring the metabolic expression of Salinispora recovered from different sites may furnish insights into their environmental adaptation or their chemical communication and, further, may lead to the discovery of new natural products. We describe the first occurrence of Salinispora strains in sediments from the Saint Peter and Saint Paul Archipelago (a collection of islets in Brazil) in the Atlantic Ocean, and we investigate the metabolic profiles of these strains by employing mass-spectrometry-based metabolomic approaches, including molecular networking from the Global Natural Products Social Molecular Networking platform. Furthermore, we analyze data from Salinispora strains recovered from sediments from the Madeira Archipelago (Portugal, Macaronesia) in order to provide a wider metabolomic investigation of Salinispora strains from the Atlantic Oceanic islands. Overall, our study evidences a broader geographic influence on the secondary metabolism of Salinispora than was previously proposed. Still, some biosynthetic gene clusters, such as those corresponding to typical chemical signatures of S. arenicola, like saliniketals and rifamycins, are highly conserved among the assessed strains.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent1865377
dc.identifier.doi10.3389/fmicb.2018.03021
dc.identifier.issn1664-302X
dc.identifier.otherPURE: 11541465
dc.identifier.otherPURE UUID: 1aebc725-f002-480a-aa8d-a836bacecbe5
dc.identifier.otherScopus: 85058385934
dc.identifier.otherWOS: 000452827100001
dc.identifier.otherPubMed: 30619120
dc.identifier.otherPubMedCentral: PMC6297358
dc.identifier.otherORCID: /0000-0002-5510-1170/work/151365652
dc.identifier.urihttp://hdl.handle.net/10362/159267
dc.identifier.urlhttps://www.scopus.com/pages/publications/85058385934
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2013/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationOcean bioprospecting: targeting marine actinomycetes as a source for lead-like drug discovery
dc.subjectLC-MS
dc.subjectMetabolomic
dc.subjectMolecular networking
dc.subjectSaliniketal
dc.subjectSalinispora
dc.subjectMicrobiology
dc.subjectMicrobiology (medical)
dc.subjectSDG 14 - Life Below Water
dc.titleMetabolomic fingerprinting of salinispora From Atlantic Oceanic Islandsen
dc.typejournal article
degois.publication.issueDEC
degois.publication.titleFrontiers in Microbiology
degois.publication.volume9
dspace.entity.typePublication
oaire.awardNumberUID/Multi/04378/2013
oaire.awardNumberIF/00700/2014/CP1224/CT0007
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleOcean bioprospecting: targeting marine actinomycetes as a source for lead-like drug discovery
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00700%2F2014%2FCP1224%2FCT0007/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamInvestigador FCT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication2a09e4c4-e04b-45e9-919f-2c3cb9f9802d
relation.isProjectOfPublication8e8d7b2c-031f-499c-b419-a0eb8bbb98f7
relation.isProjectOfPublication.latestForDiscovery8e8d7b2c-031f-499c-b419-a0eb8bbb98f7

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