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Changes in albumin-to-creatinine ratio at 12-month follow-up in patients undergoing renal denervation

2017-05Artigo científico Acesso aberto
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dc.contributor.authorSousa, Henrique
dc.contributor.authorBranco, Patrícia
dc.contributor.authorde Sousa Almeida, Manuel
dc.contributor.authorde Araújo Gonçalves, Pedro
dc.contributor.authorGaspar, Augusta
dc.contributor.authorDores, Hélder
dc.contributor.authorMesquita, João Rodrigo
dc.contributor.authorAndrade, Maria João
dc.contributor.authorNeuparth, Nuno
dc.contributor.authorAleixo, Ana
dc.contributor.authorMendes, Miguel
dc.contributor.authorBarata, José Diogo
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblSociedade Portuguesa de Cardiologia | Elsevier
dc.date.accessioned2023-01-27T22:09:13Z
dc.date.available2023-01-27T22:09:13Z
dc.date.issued2017-05
dc.description.abstractIntroduction: Sympathetic renal denervation (RDN) was developed as a treatment for the management of patients with resistant hypertension. This procedure may have a positive impact on hypertension-related target organ damage, particularly renal disease, but the evidence is still limited. Objective: To assess the impact of RDN on the albumin-to-creatinine ratio (ACR) at 12-month follow-up. Methods and Results: From a single-center prospective registry including 65 patients with resistant hypertension undergoing renal denervation, 31 patients with complete baseline and 12-month follow-up blood pressure (BP) measurements (both office and 24-h ambulatory blood pressure monitoring [ABPM]) and ACR were included in the present study. Mean age was 65±7 years, 52% were female, most (90%) had been diagnosed with hypertension for more than 10 years, 71% had type 2 diabetes and 33% had vascular disease in at least one territory. Mean estimated glomerular filtration rate was 73.6±25.1 ml/min/1.73 m2 and 15 patients (48%) had an ACR >30 mg/g. After 12 months, 22 patients were considered BP responders (73%). ACR decreased significantly from a median of 25.8 mg/g (interquartile range [IQR] 9.0-574.0 mg/g) to 14.8 mg/g (IQR 4.5-61.0 mg/g, p=0.007). When the results were split according to systolic BP responder status on ABPM, we found a significant reduction in responders (from 25.6 mg/g [IQR 8.7-382.8 mg/g] to 15.9 mg/g [IQR 4.4-55.0 mg/g], p=0.009), and a numerical decrease in the non-responder subgroup (from 165.0 mg/g [IQR 8.8-1423.5 mg/g] to 13.6 mg/dl [IQR 5.7-1417.0 mg/g], p=0.345). Conclusions: Besides significant reductions in blood pressure (both office and 24-h ABPM), renal denervation was associated with a significant reduction in ACR, a recognized marker of target organ damage.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent728151
dc.identifier.doi10.1016/j.repc.2016.09.019
dc.identifier.issn0870-2551
dc.identifier.otherPURE: 2763223
dc.identifier.otherPURE UUID: 3a156269-6fee-46fb-b154-6918098dd82b
dc.identifier.otherScopus: 85018706617
dc.identifier.otherPubMed: 28456548
dc.identifier.otherWOS: 000402001100003
dc.identifier.otherORCID: /0000-0001-5149-7473/work/196571873
dc.identifier.urihttp://hdl.handle.net/10362/148248
dc.identifier.urlhttps://www.scopus.com/pages/publications/85018706617
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAlbuminuria
dc.subjectBlood pressure
dc.subjectRenal denervation
dc.subjectResistant hypertension
dc.subjectCardiology and Cardiovascular Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleChanges in albumin-to-creatinine ratio at 12-month follow-up in patients undergoing renal denervationen
dc.typejournal article
degois.publication.firstPage343
degois.publication.issue5
degois.publication.lastPage351
degois.publication.titleRevista Portuguesa de Cardiologia
degois.publication.volume36
dspace.entity.typePublication
rcaap.rightsopenAccess

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