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Do ethnicity, degree of family relationship, and the spondyloarthritis subtype in affected relatives influence the association between a positive family history for spondyloarthritis and HLA-B27 carriership?

2018-08-03Artigo científico Acesso aberto
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dc.contributor.authorvan Lunteren, Miranda
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorLandewé, Robert
dc.contributor.authorSieper, Joachim
dc.contributor.authorRudwaleit, Martin
dc.contributor.authorvan der Heijde, Désirée
dc.contributor.authorvan Gaalen, Floris
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2018-10-12T22:15:40Z
dc.date.available2018-10-12T22:15:40Z
dc.date.issued2018-08-03
dc.description.abstractBACKGROUND: The Assessment of SpondyloArthritis international Society (ASAS) defines a positive family history (PFH) of spondyloarthritis (SpA) as the presence of ankylosing spondylitis (AS), acute anterior uveitis (AAU), reactive arthritis (ReA), inflammatory bowel disease (IBD), and/or psoriasis in first-degree relatives (FDR) or second-degree relatives (SDR). In two European cohorts, a PFH of AS and AAU, but not other subtypes, was associated with human leukocyte antigen B27 (HLA-B27) carriership in patients suspected of axial SpA (axSpA). Because the importance of ethnicity or degree of family relationship is unknown, we investigated the influence of ethnicity, FDR, or SDR on the association between a PFH and HLA-B27 carriership in patients suspected of axSpA. METHODS: Baseline data from the ASAS cohort of patients suspected of axSpA were analyzed. Univariable analyses were performed. Each disease (AS, AAU, psoriasis, IBD, ReA) in a PFH according to the ASAS definition was a determinant in separate models with HLA-B27 carriership as outcome. Analyses were stratified for self-reported ethnicity, FDR, and SDR. Analyses were repeated in multivariable models to investigate independent associations. RESULTS: A total of 594 patients were analyzed (mean [SD] age 33.7 [11.7] years; 46% male; 52% HLA-B27+; 59% white, 36% Asian, 5% other). A PFH was associated with HLA-B27 carriership in patients with a white (OR, 2.3, 95% CI, 1.4-3.9) or Asian ethnicity (OR, 3.1, 95% CI, 1.6-5.8) and with a PFH in FDR (OR, 2.9, 95% CI, 1.8-4.5), but not with a PFH in SDR (OR, 1.7, 95% CI, 0.7-3.8) or in other ethnicities. A PFH of AS was positively associated with HLA-B27 carriership in all subgroups (white OR, 7.1; 95% CI, 2.9-17.1; Asian OR, 5.7; 95% CI, 2.5-13.2; FDR OR, 7.8; 95% CI, 3.8-16.0; SDR OR, 3.7; 95% CI, 1.2-11.6). A PFH of AAU, ReA, IBD, or psoriasis was never positively associated with HLA-B27 carriership. In the multivariate analysis, similar results were found. CONCLUSIONS: In the ASAS cohort, a PFH of AS, but not of AAU, ReA, IBD, or psoriasis, was associated with HLA-B27 carriership regardless of white or Asian ethnicity or degree of family relationship. This cohort and two European cohorts show that a PFH of AS and possibly a PFH of AAU can be used to identify patients who are more likely to be HLA-B27-positive and therefore may have an increased risk of axSpA.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent552301
dc.identifier.doi10.1186/s13075-018-1672-2
dc.identifier.issn1478-6362
dc.identifier.otherPURE: 6016887
dc.identifier.otherPURE UUID: efee3ec7-16e4-49ea-a934-c0598d0712f7
dc.identifier.otherPubMed: 30075809
dc.identifier.otherPubMedCentral: PMC6091114
dc.identifier.otherWOS: 000441209200005
dc.identifier.otherScopus: 85051073310
dc.identifier.urihttp://hdl.handle.net/10362/48799
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAxial spondyloarthritis
dc.subjectHLA-B2
dc.subjectPositive family histor
dc.subjectEthnicity
dc.subjectDegree of family relationship
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDo ethnicity, degree of family relationship, and the spondyloarthritis subtype in affected relatives influence the association between a positive family history for spondyloarthritis and HLA-B27 carriership?en
dc.title.subtitleResults from the worldwide ASAS cohorten
dc.typejournal article
degois.publication.firstPage
degois.publication.issue1
degois.publication.lastPage
degois.publication.titleArthritis Research & Therapy
degois.publication.volume20
dspace.entity.typePublication
person.familyNameSepriano
person.givenNameAlexandre
person.identifier397398
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.orcid0000-0003-1954-0229
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication.latestForDiscoveryd87df0c7-841b-4648-a99e-296348e2e286

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