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Building on surface-active ionic liquids for the rescuing of the antimalarial drug chloroquine

2020-07-27Artigo científico Acesso aberto
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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorLobo, Lis
dc.contributor.authorOliveira, Isabel S.
dc.contributor.authorGomes, Joana
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorNogueira, Fátima
dc.contributor.authorMarques, Eduardo F.
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGomes, Paula
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-05-01T22:52:55Z
dc.date.available2021-05-01T22:52:55Z
dc.date.issued2020-07-27
dc.description.abstractIonic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50 values of 4 and 110 nM against a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium falciparum, respectively, corresponding to an 11-and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the same strains. This unprecedented report opens new perspectives in both the fields of malaria chemotherapy and of surface-active ionic liquids derived from active pharmaceutical ingredients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9
dc.format.extent724417
dc.identifier.doi10.3390/ijms21155334
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 26671128
dc.identifier.otherPURE UUID: 90caeec7-7358-4d6e-9bed-0ab6bda1f8be
dc.identifier.otherScopus: 85088851023
dc.identifier.otherPubMed: 32727096
dc.identifier.otherPubMedCentral: PMC7432003
dc.identifier.otherORCID: /0000-0003-0313-0778/work/124583120
dc.identifier.urihttp://hdl.handle.net/10362/116628
dc.identifier.urlhttps://www.scopus.com/pages/publications/85088851023
dc.identifier.urlhttps://www.mdpi.com/1422-0067/21/15/5334
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAntimalarial
dc.subjectChloroquine
dc.subjectIonic liquid
dc.subjectMalaria
dc.subjectRepurposing
dc.subjectRescuing
dc.subjectSurface active
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectParasitology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBuilding on surface-active ionic liquids for the rescuing of the antimalarial drug chloroquineen
dc.typejournal article
degois.publication.firstPage5334
degois.publication.issue15
degois.publication.lastPage5343
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume21
dspace.entity.typePublication
rcaap.rightsopenAccess

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