Logo do repositório
 
Publicação

Rapid determination of antituberculosis drug resistance from wholegenome sequences.

2015Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorColl, Francesc
dc.contributor.authorMcNerney, Ruth
dc.contributor.authorPreston, Mark D.
dc.contributor.authorGuerra-Assunção, José Afonso
dc.contributor.authorWarry, Andrew
dc.contributor.authorHill-Cawthorne, Grant
dc.contributor.authorMallard, Kim
dc.contributor.authorNair, Mridul
dc.contributor.authorMiranda, Anabela
dc.contributor.authorAlves, Adriana
dc.contributor.authorPerdigão, João
dc.contributor.authorViveiros, M
dc.contributor.authorPortugal, Isabel
dc.contributor.authorHasan, Zahra
dc.contributor.authorHasan, Rumina
dc.contributor.authorGlynn, Judith R.
dc.contributor.authorMartin, Nigel
dc.contributor.authorPain, Arnab
dc.contributor.authorClark, Taane G.
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2018-05-14T22:05:35Z
dc.date.available2018-05-14T22:05:35Z
dc.date.issued2015
dc.description.abstractMycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application. A library (1,325 mutations) predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using genomic-phenotypic data from 792 strains. A rapid online ‘TB-Profiler’ tool was developed to report DR and strain-type profiles directly from raw sequences. Using our DR mutation library, in silico diagnostic accuracy was superior to some commercial diagnostics and alternative databases. The library will facilitate sequence-based drug-susceptibility testing.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1200672
dc.identifier.doi10.1186/s13073-015-0164-0
dc.identifier.otherPURE: 4033368
dc.identifier.otherPURE UUID: a23ae027-1c01-43fc-be6c-50bc92ddd037
dc.identifier.otherORCID: /0000-0001-9676-6251/work/45270565
dc.identifier.urihttp://hdl.handle.net/10362/37000
dc.language.isoeng
dc.peerreviewedyes
dc.subjectSDG 3 - Good Health and Well-being
dc.titleRapid determination of antituberculosis drug resistance from wholegenome sequences.en
dc.typejournal article
degois.publication.titleGenome Medicine
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Rapid_determination_of_antituberculosis_drug_resistance_from_wholegenome_sequences.pdf
Tamanho:
1.15 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IHMT: MM - Artigos em revista internacional com arbitragem científica