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Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy

2023-04-25Artigo científico Acesso aberto
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dc.contributor.authorSantos, Filipa
dc.contributor.authorPires, David
dc.contributor.authorAnes, Elsa
dc.contributor.authorDuarte, Ana Rita C.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblElsevier
dc.date.accessioned2023-06-28T22:19:08Z
dc.date.available2023-06-28T22:19:08Z
dc.date.issued2023-04-25
dc.descriptionFunding Information: This project has received funding from the European Union’s Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry-LAQV. We also thank the support of ADEIM-FFUL (Associação para o Ensino e a Investigação em Microbiologia). Publisher Copyright: © 2023 The Author(s)
dc.description.abstractTherapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent12
dc.format.extent2126029
dc.identifier.doi10.1016/j.ijpharm.2023.122862
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 64822282
dc.identifier.otherPURE UUID: 5f92adde-e762-4aaf-9edc-c7e2d70ec75d
dc.identifier.otherScopus: 85151041781
dc.identifier.otherWOS: 000967066300001
dc.identifier.otherPubMed: 36965645
dc.identifier.otherORCID: /0000-0003-0800-0112/work/151371924
dc.identifier.urihttp://hdl.handle.net/10362/154569
dc.identifier.urlhttps://www.scopus.com/pages/publications/85151041781
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationResearch Institute for Medicines
dc.subjectAnti-tuberculosis drugs
dc.subjectEutectic mixtures
dc.subjectTherapeutic liquid mixtures
dc.subjectTuberculosis
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleInsights into therapeutic liquid mixtures and formulations towards tuberculosis therapyen
dc.typejournal article
degois.publication.titleInternational Journal of Pharmaceutics
degois.publication.volume637
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberPTDC/SAU-INF/28182/2017
oaire.awardNumberUID/DTP/04138/2019
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleResearch Institute for Medicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-INF%2F28182%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication81f70deb-e258-413e-93b9-af993ddc03ae
relation.isProjectOfPublication1e9b3df0-e475-41f1-a5ee-94d3f562a421
relation.isProjectOfPublication.latestForDiscoveryadc84c24-ba1d-4bcd-b753-2128ce9a5faa

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