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The Role of the Cephalopod Digestive Gland in the Storage and Detoxification of Marine Pollutants

2017-04-20Artigo científico Acesso aberto
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dc.contributor.authorRodrigo, Ana P.
dc.contributor.authorCosta, Pedro M
dc.contributor.institutionDCEA - Departamento de Ciências e Engenharia do Ambiente
dc.contributor.institutionMARE - Centro de Ciências do Mar e do Ambiente
dc.contributor.pblFrontiers
dc.date.accessioned2018-03-22T23:15:18Z
dc.date.available2018-03-22T23:15:18Z
dc.date.issued2017-04-20
dc.descriptionCOST Action FA1301 "A network for improvement of cephalopod welfare and husbandry in research, aquaculture and fisheries (CephsInAction)" The Portuguese Foundation for Science and Technology (FCT) MARE through the strategic programme (UID/MAR/04292/2013; SFRH/BD/109462/2015; IF/00265/2015) GreenTech (PTDC/MARBIO/0113/2014) FCT
dc.description.abstractThe relevance of cephalopods for fisheries and even aquaculture, is raising concerns on the relationship between these molluscs and environmental stressors, from climate change to pollution. However, how these organisms cope with environmental toxicants is far less understood than for other molluscs, especially bivalves, which are frontline models in aquatic toxicology. Although, sharing the same basic body plan, cephalopods hold distinct adaptations, often unique, as they are active predators with high growth and metabolic rates. Most studies on the digestive gland, the analog to the vertebrate liver, focused on metal bioaccumulation and its relation to environmental concentrations, with indication for the involvement of special cellular structures (like spherulae) and proteins. Although the functioning of phase I and II enzymes of detoxification in molluscs is controversial, there is evidence for CYP-mediated bioactivation, albeit with lower activity than vertebrates, but this issue needs yet much research. Through novel molecular tools, toxicology-relevant genes and proteins are being unraveled, from metallothioneins to heat-shock proteins and phase II conjugation enzymes, which highlights the importance of increasing genomic annotation as paramount to understand toxicant-specific pathways. However, little is known on how organic toxicants are stored, metabolized and eliminated, albeit some evidence from biomarker approaches, particularly those related to oxidative stress, suggesting that these molluscs' digestive gland is indeed responsive to chemical aggression. Additionally, cause-effect relationships between pollutants and toxicopathic effects are little understood, thus compromising, if not the deployment of these organisms for biomonitoring, at least understanding how they are affected by anthropogenically-induced global change.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3019600
dc.identifier.doi10.3389/fphys.2017.00232
dc.identifier.issn1664-042X
dc.identifier.otherPURE: 2750457
dc.identifier.otherPURE UUID: 0e289dd5-e2cb-4eb2-8cb9-f7437f5b4bbe
dc.identifier.otherPubMed: 28473775
dc.identifier.otherPubMedCentral: PMC5397501
dc.identifier.otherScopus: 85018784698
dc.identifier.otherWOS: 000402871600001
dc.identifier.urihttp://hdl.handle.net/10362/33073
dc.language.isoeng
dc.peerreviewedyes
dc.subjectquatic toxicology
dc.subjectmollusca
dc.subjectCephalopoda
dc.subjectbiomarkers
dc.subjecttoxicological pathways
dc.subjectbioaccumulation
dc.subjectSDG 13 - Climate Action
dc.subjectSDG 14 - Life Below Water
dc.titleThe Role of the Cephalopod Digestive Gland in the Storage and Detoxification of Marine Pollutantsen
dc.typejournal article
degois.publication.titleFrontiers in Physiology
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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