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Green Sol–Gel Synthesis of Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications

2024-12Artigo científico Acesso aberto
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dc.contributor.authorJesus, Juliana
dc.contributor.authorRegadas, Joana
dc.contributor.authorCosta, Bárbara
dc.contributor.authorCarvalho, João
dc.contributor.authorPádua, Ana
dc.contributor.authorHenriques, Célia
dc.contributor.authorSoares, Paula I.P.
dc.contributor.authorGavinho, Sílvia
dc.contributor.authorValente, Manuel A.
dc.contributor.authorGraça, Manuel P.F.
dc.contributor.authorSoreto, Sílvia
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-02-10T21:18:05Z
dc.date.available2025-02-10T21:18:05Z
dc.date.issued2024-12
dc.descriptionA. Sofia Pádua and J.P. Carvalho acknowledge the FCT—Portuguese Foundation for Science and Technology for PhD grants (UI/DB/151287/2021 and 2024.00842.BD, respectively). Publisher Copyright: © 2024 by the authors.
dc.description.abstractBackground/Objectives: The unique properties of iron oxide nanoparticles have attracted significant interest within the biomedical community, particularly for magnetic hyperthermia applications. Various synthesis methods have been developed to optimize these nanoparticles. Methods: In this study, we employed a powdered coconut water (PCW)-assisted sol–gel method to produce magnetite nanoparticles for the first time. A comprehensive analysis of the thermal (differential thermal analysis and thermogravimetry), structural (X-ray diffraction), morphological (scanning electron microscopy with energy dispersive spectroscopy), magnetic (vibrating sample magnetometer and hyperthermia), and biological (cytotoxicity essays) properties was conducted to assess their potential for magnetic hyperthermia. Results: Samples heat-treated at 700 °C and 400 °C (washed powder) for 4 h under argon presented only magnetite in their composition. The micrometer-sized particles exhibited ferrimagnetic behavior, with saturation magnetization values of 37, 76, and 10 emu/g and specific absorption rates (SAR) of 27.1, 19.9, and 14.1 W/g, respectively, for treatments at 350 °C (48 h), 700 °C (4 h), and 400 °C (washed powder, 4 h) under an argon atmosphere. Biological tests showed no cytotoxicity below 10 mg/mL. Conclusions: The findings highlight the potential of PCW-assisted synthesis as a sustainable and efficient strategy for producing pure magnetite, with powder washing preceding the heat treatment enabling the attainment of this phase at lower temperatures. Nevertheless, the micrometer-scale dimensions is observed in the morphological analysis limit their suitability for biomedical applications.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4039321
dc.identifier.doi10.3390/pharmaceutics16121578
dc.identifier.issn1999-4923
dc.identifier.otherPURE: 108334140
dc.identifier.otherPURE UUID: 24357b3a-fbe7-4975-a854-ce2dfba9bfa6
dc.identifier.otherScopus: 85213400271
dc.identifier.otherWOS: 001383907200001
dc.identifier.otherWOS: 39771557
dc.identifier.otherORCID: /0000-0003-2711-1184/work/177783734
dc.identifier.urihttp://hdl.handle.net/10362/178767
dc.identifier.urlhttps://www.scopus.com/pages/publications/85213400271
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.subjectcancer
dc.subjectcoconut water powder
dc.subjectmagnetic hyperthermia
dc.subjectmagnetite
dc.subjectnanoparticles
dc.subjectsol–gel
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGreen Sol–Gel Synthesis of Iron Oxide Nanoparticles for Magnetic Hyperthermia Applicationsen
dc.typejournal article
degois.publication.issue12
degois.publication.titlePharmaceutics
degois.publication.volume16
dspace.entity.typePublication
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication1f28ae2f-dfab-4e75-a2f7-62ed25a680b6
relation.isProjectOfPublication4b1cd3c6-a456-4abc-8246-39c79dc9ec18
relation.isProjectOfPublication.latestForDiscovery4b1cd3c6-a456-4abc-8246-39c79dc9ec18

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