Logo do repositório
 
Publicação

Application of hyperthermia for cancer treatment: Synthesis and characterization of magnetic nanoparticles and their internalization on tumor cell lines

2019-04-15Documento de conferência Acesso aberto
Ver registo simples
dc.contributor.authorChaparro, Catarina I. P.
dc.contributor.authorLoureiro, Liliana R.
dc.contributor.authorValente, Manuel Almeida
dc.contributor.authorVideira, Paula A.
dc.contributor.authorBorges, João Paulo
dc.contributor.authorSoares, Paula I. P.
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.date.accessioned2021-03-26T23:32:47Z
dc.date.available2021-03-26T23:32:47Z
dc.date.issued2019-04-15
dc.descriptionFEDER funds through the COMPETE 2020 Program under the project number POCI-01-0145-FEDER-007688. This work was also funded by the Scientific merit prize Santander-Totta - Lisbon New University - "Antibody engineering for breast cancer therapy" 2013. Catarina I. P. Chaparro also acknowledges the financial support from Liga Portuguesa Contra o Cancro (LPCC)/Pfizer 2017.
dc.description.abstractTruncated sialylated O-glycans, such as cell-surface carbohydrate antigen sialyl-Tn (STn) are overexpressed by several cancer types, but not by the respective normal tissues. STn expression is associated with oncogenesis and metastatic ability of cancer cells, with reduced overall survival and lack of response to chemotherapy. Advances in nanomedicine have resulted in rapid development of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with considerable potential in cancer treatment. Therefore, in this study SPIONs coated with oleic acid (OA) or dimercaptosuccinic acid (DMSA) were developed and characterized for internalization in two breast cancer cell lines: cell line expressing the STn antigen and the corresponding control. SPIONs with an average diameter of 8 nm showed superparamagnetic behavior and high potential to be used as magnetic hyperthermia agents. OA and DMSA coating provided high stability of SPIONs in physiological conditions while not changing their main properties. NPs internalization studies showed a higher accumulation of DMSA coated NPs in the breast cancer MDA-MB-231 WT cell line. In MDA-MB-231 cell line expressing STn both coated NPs showed a similar accumulation. Therefore, STn antigen can act as a receptor capable of detecting and covalently bind to the molecules present on NPs surface and induce their cellular uptake by endocytosis.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3112505
dc.identifier.doi10.1109/ENBENG.2019.8692485
dc.identifier.isbn9781538685068
dc.identifier.otherPURE: 13266567
dc.identifier.otherPURE UUID: 827763d6-ae4b-465d-aaa9-e47232f2e170
dc.identifier.otherScopus: 85065489838
dc.identifier.otherORCID: /0000-0001-5987-2485/work/64041219
dc.identifier.otherORCID: /0000-0002-3996-6545/work/67751067
dc.identifier.urihttp://hdl.handle.net/10362/114540
dc.identifier.urlhttps://www.scopus.com/pages/publications/85065489838
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147333/PT
dc.subjectBioengineering
dc.subjectSDG 3 - Good Health and Well-being
dc.titleApplication of hyperthermia for cancer treatment: Synthesis and characterization of magnetic nanoparticles and their internalization on tumor cell linesen
dc.typeconference object
degois.publication.title6th IEEE Portuguese Meeting on Bioengineering, ENBENG 2019 - Proceedings
degois.publication.title6th IEEE Portuguese Meeting on Bioengineering, ENBENG 2019
dspace.entity.typePublication
oaire.awardNumber147333
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/147333/PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication4feabffc-4782-4bcd-8f7d-aaac8c3f2325
relation.isProjectOfPublication.latestForDiscovery4feabffc-4782-4bcd-8f7d-aaac8c3f2325

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
chaparro2019.pdf
Tamanho:
2.97 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

FCT: CENIMAT - Documentos de conferências nacionais