Logo do repositório
 
Publicação

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy

2025-11Recensão Acesso aberto
Ver registo simples
dc.contributor.authorMarcuello, Carlos
dc.contributor.authorLim, Kee Siang
dc.contributor.authorNisini, Giacomo
dc.contributor.authorPokrovsky, Vadim S.
dc.contributor.authorConde, João
dc.contributor.authorRuggeri, Francesco Simone
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblJohn Wiley and Sons Inc.
dc.date.accessioned2025-10-23T21:58:15Z
dc.date.available2025-10-23T21:58:15Z
dc.date.issued2025-11
dc.descriptionPublisher Copyright: © 2025 The Author(s). Small Science published by Wiley-VCH GmbH.
dc.description.abstractNanobiomedicine promises to revolutionize life quality and expectancy of patients with cognitive impairment and cancer malignancies, via unraveling key molecular processes related to their onset useful as biomarkers of disease to develop and improve the efficacy of therapies. However, it is still a challenge understanding and identifying these molecular mechanisms as biomarkers of disease, because of their high-level of polymorphism and nanoscale dimensions. Here, it provides a review work linking the potential and capabilities of atomic force microscopy (AFM) technologies in unraveling beyond imaging the common and hidden properties of transient and nanosized molecular processes in cancer and neurodegeneration. This study highlights the most prominent operational modes of AFM to achieve morphological, mechanical, and chemical characterization of the molecular processes leading to these diseases. Finally, it outlines the advantages of AFM compared with other techniques to guide newcomers and stakeholders toward potential future avenues opened by AFM methods in nanobiomedicine.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17213157
dc.identifier.doi10.1002/smsc.202500351
dc.identifier.issn2688-4046
dc.identifier.otherPURE: 132924455
dc.identifier.otherPURE UUID: 43920f02-46f7-4e2b-bd96-3608cd8cb7ca
dc.identifier.otherScopus: 105018706651
dc.identifier.otherPubMed: 41256193
dc.identifier.urihttp://hdl.handle.net/10362/189671
dc.identifier.urlhttps://www.scopus.com/pages/publications/105018706651
dc.language.isoeng
dc.peerreviewedyes
dc.subjectamyloidogenic proteins
dc.subjectatomic force microscopy
dc.subjectbiomolecular processes
dc.subjectcancer diseases
dc.subjectforce spectroscopy
dc.subjectnano-chemical analysis
dc.subjectneurodegeneration
dc.subjectCatalysis
dc.subjectChemical Engineering (miscellaneous)
dc.subjectMaterials Science (miscellaneous)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNanoscale Analysis beyond Imaging by Atomic Force Microscopyen
dc.title.subtitleMolecular Perspectives on Oncology and Neurodegenerationen
dc.typereview
degois.publication.issue11
degois.publication.titleSmall Science
degois.publication.volume5
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Small_Science_-_2025_-_Marcuello_-_Nanoscale_Analysis_beyond_Imaging_by_Atomic_Force_Microscopy_Molecular_Perspectives_on.pdf
Tamanho:
16.42 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CHRC - Artigos em revista internacional com arbitragem científica