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Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation

2021-05-01Artigo científico Acesso aberto
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dc.contributor.authorCraveiro, Rita
dc.contributor.authorCastro, Vânia I. B.
dc.contributor.authorViciosa, Maria Teresa
dc.contributor.authorDionísio, Madalena
dc.contributor.authorReis, R. L.
dc.contributor.authorDuarte, Ana Rita C.
dc.contributor.authorPaiva, Alexandre
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblElsevier
dc.date.accessioned2021-10-09T04:55:36Z
dc.date.available2021-10-09T04:55:36Z
dc.date.issued2021-05-01
dc.descriptionthe agreement number ERC-2016-CoG 725034 (ERC Consolidator PTDC/EQU-EQU/29851/2017
dc.description.abstractNatural deep eutectic systems (NADES), which have applications as solvents for both engineering and life sciences, are mainly composed of sugars, aminoacids or organic acids. In this work NADES composed by glucose, urea and proline (G:U:P in a molar ratio of 1:1:1) and proline and glucose (P:G 5:3) were prepared and added in different mass fractions to water. By differential scanning calorimetry it was verified as the crystallization tendency of water is modified even for low fraction of NADES added. This is also observed by polarized optical microscopy which allowed following the formation of crystals with different crystalline morphologies as bulk water. Calorimetric data also shown as the crystallization temperature decreases for all P:G mixtures and this shift is more accentuated for weight fraction of NADES higher than 0.5. Crystallization is totally suppressed for NADES fraction higher than 0.7. NADES/water mixtures cytotoxicity was evaluated in vitro, revealing that they are less toxic as compared with the commonly used cryoprotective additives as dimethyl sulfoxide (DMSO). Additionally, cell viability tests with cell lines cryopreserved using DMSO and both the prepared NADES showed comparable viability. This work combines thermophysical data on NADES and evaluates it's in vitro performance, providing cues for their use in cryopreservation applications.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2432528
dc.identifier.doi10.1016/j.molliq.2021.115533
dc.identifier.issn0167-7322
dc.identifier.otherPURE: 28466706
dc.identifier.otherPURE UUID: d50a88f8-53ed-41e0-aab2-26113e72f6d7
dc.identifier.otherScopus: 85100660843
dc.identifier.otherWOS: 000636646200044
dc.identifier.otherORCID: /0000-0003-0800-0112/work/101182582
dc.identifier.otherORCID: /0000-0002-1487-0889/work/101182628
dc.identifier.urihttp://hdl.handle.net/10362/125817
dc.identifier.urlhttps://www.scopus.com/pages/publications/85100660843
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
dc.relationDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.subjectCytotoxicity
dc.subjectGlucose
dc.subjectNADES
dc.subjectProline
dc.subjectThermal properties
dc.subjectUrea
dc.subjectWater mixtures
dc.subjectElectronic, Optical and Magnetic Materials
dc.subjectAtomic and Molecular Physics, and Optics
dc.subjectCondensed Matter Physics
dc.subjectSpectroscopy
dc.subjectPhysical and Theoretical Chemistry
dc.subjectMaterials Chemistry
dc.titleInfluence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservationen
dc.typejournal article
degois.publication.titleJournal of Molecular Liquids
degois.publication.volume329
dspace.entity.typePublication
oaire.awardNumberIF/01146/2015/CP1293/CT0003
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardTitleDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.fundingStreamInvestigador FCT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication76b83429-52bd-44c7-9033-57fa453f15ae
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication4d9a4d40-4803-4f3a-976b-d6eaaef42510
relation.isProjectOfPublication.latestForDiscovery4d9a4d40-4803-4f3a-976b-d6eaaef42510

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