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Epicardial Adipose Tissue

2021Artigo científico Acesso aberto
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dc.contributor.authorSousa, João Adriano
dc.contributor.authorMendonça, Maria Isabel
dc.contributor.authorSerrão, Marco
dc.contributor.authorBorges, Sofia
dc.contributor.authorHenriques, Eva
dc.contributor.authorFreitas, Sónia
dc.contributor.authorTentem, Margarida
dc.contributor.authorSantos, Marina
dc.contributor.authorFreitas, Pedro
dc.contributor.authorFerreira, António
dc.contributor.authorGuerra, Graça
dc.contributor.authorDrumond, António
dc.contributor.authorPalma dos Reis, Roberto
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblLibertas Academica
dc.date.accessioned2021-11-03T05:02:52Z
dc.date.available2021-11-03T05:02:52Z
dc.date.issued2021
dc.descriptionPublisher Copyright: © The Author(s) 2021.
dc.description.abstractEvidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent352542
dc.identifier.doi10.1177/11795468211029244
dc.identifier.otherPURE: 34296806
dc.identifier.otherPURE UUID: 0d5b80a2-1bab-419b-9b98-1a8b78248b42
dc.identifier.otherScopus: 85109104903
dc.identifier.otherWOS: 000688484800001
dc.identifier.urihttp://hdl.handle.net/10362/127060
dc.identifier.urlhttps://www.scopus.com/pages/publications/85109104903
dc.language.isoeng
dc.peerreviewedyes
dc.subjectatherosclerosis
dc.subjectcardiovascular risk factors
dc.subjectEpicardial adipose tissue
dc.subjectgenetic polymorphisms
dc.subjectGenetic Risk Score
dc.subjectCardiology and Cardiovascular Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEpicardial Adipose Tissueen
dc.title.subtitleThe Genetics Behind an Emerging Cardiovascular Risk Markeren
dc.typejournal article
degois.publication.titleClinical Medicine Insights: Cardiology
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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